Effective use of a sodium-hyaluronate spray formulation in oral mucositis

Colella, G; Vicidomini, A

Risultato della ricerca: Paper

Abstract

Background andaims: Orai mucositis (OM) is one of thè most frequent and potentially severe acute side effect of non-surgical cancer therapy which often leads to significant morbidity, mortality and decreased quality of life. Today a standard and universally accepted management strategy to prevent and treat it does not exist. Given thè key role played by connective damage in its pathogenesis, thè use of a compound which promotes thè extracellular matrix regeneration couìd be a valid therapeutic strategy. In this regard, thè use of hyaluronic acid, that plays an important role in orai lissue healing by means of several mechanisms, has been showed to provide good results in managing OM. The aim of this open clinical trial is to assess thè effects of a spray compound containing a pool of collagen precursor synthetic aminoacids (1-proline, 1-SeucÌne. 1- lysine and giycine) combined with sodium hyaluronate in thè treatment of OM. Materials and methods: Fifty-four patients with OM were consecutively and unseiec- tively recruited. The treatment efficacy was evaluated on (i) pain score, (ii) clinicaì resolution index (CRI) and (iii) WHO Mucositis scale recorded at times TO (baseline). T01 (2 h), TI (24 h), T2 (72 h), T3 (7 days) and T4 (14 days). Results: The application of thè spray showed a significant reduction in paìn after only 2 h compared with baseline measurements (P < 0.0001). A progressive reduction of pain through thè 2 weeks was also noted (P < 0.0001). Patient ìesions treated with thè spray also significantly improved after 72 h of treatment both in terms of CRI (P = 0.0186) and as WHO Mucositis score (P < 0.0001). Conclusions and relevance: Although further studies are recommended. our fìndings confimi that spray formulation may offer rapid and effective paìn management aiding a fast mucosal wound healing with consequent improvement of thè ability to eat anc drink which usually compromises patients suffering from OM.
Lingua originaleEnglish
Stato di pubblicazionePublished - 2012

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Stomatitis
Mucositis
Hyaluronic Acid
Pain
Aptitude
Pain Management
Therapeutics
Proline
Wound Healing
Lysine
Extracellular Matrix
Regeneration
Collagen
Quality of Life
Clinical Trials
Morbidity
Mortality

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Effective use of a sodium-hyaluronate spray formulation in oral mucositis. / Colella, G; Vicidomini, A.

2012.

Risultato della ricerca: Paper

@conference{bd5aa4a079a043a081b5f4b7acce5c23,
title = "Effective use of a sodium-hyaluronate spray formulation in oral mucositis",
abstract = "Background andaims: Orai mucositis (OM) is one of th{\`e} most frequent and potentially severe acute side effect of non-surgical cancer therapy which often leads to significant morbidity, mortality and decreased quality of life. Today a standard and universally accepted management strategy to prevent and treat it does not exist. Given th{\`e} key role played by connective damage in its pathogenesis, th{\`e} use of a compound which promotes th{\`e} extracellular matrix regeneration cou{\`i}d be a valid therapeutic strategy. In this regard, th{\`e} use of hyaluronic acid, that plays an important role in orai lissue healing by means of several mechanisms, has been showed to provide good results in managing OM. The aim of this open clinical trial is to assess th{\`e} effects of a spray compound containing a pool of collagen precursor synthetic aminoacids (1-proline, 1-Seuc{\`I}ne. 1- lysine and giycine) combined with sodium hyaluronate in th{\`e} treatment of OM. Materials and methods: Fifty-four patients with OM were consecutively and unseiec- tively recruited. The treatment efficacy was evaluated on (i) pain score, (ii) clinica{\`i} resolution index (CRI) and (iii) WHO Mucositis scale recorded at times TO (baseline). T01 (2 h), TI (24 h), T2 (72 h), T3 (7 days) and T4 (14 days). Results: The application of th{\`e} spray showed a significant reduction in pa{\`i}n after only 2 h compared with baseline measurements (P < 0.0001). A progressive reduction of pain through th{\`e} 2 weeks was also noted (P < 0.0001). Patient {\`i}esions treated with th{\`e} spray also significantly improved after 72 h of treatment both in terms of CRI (P = 0.0186) and as WHO Mucositis score (P < 0.0001). Conclusions and relevance: Although further studies are recommended. our f{\`i}ndings confimi that spray formulation may offer rapid and effective pa{\`i}n management aiding a fast mucosal wound healing with consequent improvement of th{\`e} ability to eat anc drink which usually compromises patients suffering from OM.",
author = "{Colella, G; Vicidomini, A} and Giuseppina Campisi and Fabio Fulfaro and Domenico Compilato",
year = "2012",
language = "English",

}

TY - CONF

T1 - Effective use of a sodium-hyaluronate spray formulation in oral mucositis

AU - Colella, G; Vicidomini, A

AU - Campisi, Giuseppina

AU - Fulfaro, Fabio

AU - Compilato, Domenico

PY - 2012

Y1 - 2012

N2 - Background andaims: Orai mucositis (OM) is one of thè most frequent and potentially severe acute side effect of non-surgical cancer therapy which often leads to significant morbidity, mortality and decreased quality of life. Today a standard and universally accepted management strategy to prevent and treat it does not exist. Given thè key role played by connective damage in its pathogenesis, thè use of a compound which promotes thè extracellular matrix regeneration couìd be a valid therapeutic strategy. In this regard, thè use of hyaluronic acid, that plays an important role in orai lissue healing by means of several mechanisms, has been showed to provide good results in managing OM. The aim of this open clinical trial is to assess thè effects of a spray compound containing a pool of collagen precursor synthetic aminoacids (1-proline, 1-SeucÌne. 1- lysine and giycine) combined with sodium hyaluronate in thè treatment of OM. Materials and methods: Fifty-four patients with OM were consecutively and unseiec- tively recruited. The treatment efficacy was evaluated on (i) pain score, (ii) clinicaì resolution index (CRI) and (iii) WHO Mucositis scale recorded at times TO (baseline). T01 (2 h), TI (24 h), T2 (72 h), T3 (7 days) and T4 (14 days). Results: The application of thè spray showed a significant reduction in paìn after only 2 h compared with baseline measurements (P < 0.0001). A progressive reduction of pain through thè 2 weeks was also noted (P < 0.0001). Patient ìesions treated with thè spray also significantly improved after 72 h of treatment both in terms of CRI (P = 0.0186) and as WHO Mucositis score (P < 0.0001). Conclusions and relevance: Although further studies are recommended. our fìndings confimi that spray formulation may offer rapid and effective paìn management aiding a fast mucosal wound healing with consequent improvement of thè ability to eat anc drink which usually compromises patients suffering from OM.

AB - Background andaims: Orai mucositis (OM) is one of thè most frequent and potentially severe acute side effect of non-surgical cancer therapy which often leads to significant morbidity, mortality and decreased quality of life. Today a standard and universally accepted management strategy to prevent and treat it does not exist. Given thè key role played by connective damage in its pathogenesis, thè use of a compound which promotes thè extracellular matrix regeneration couìd be a valid therapeutic strategy. In this regard, thè use of hyaluronic acid, that plays an important role in orai lissue healing by means of several mechanisms, has been showed to provide good results in managing OM. The aim of this open clinical trial is to assess thè effects of a spray compound containing a pool of collagen precursor synthetic aminoacids (1-proline, 1-SeucÌne. 1- lysine and giycine) combined with sodium hyaluronate in thè treatment of OM. Materials and methods: Fifty-four patients with OM were consecutively and unseiec- tively recruited. The treatment efficacy was evaluated on (i) pain score, (ii) clinicaì resolution index (CRI) and (iii) WHO Mucositis scale recorded at times TO (baseline). T01 (2 h), TI (24 h), T2 (72 h), T3 (7 days) and T4 (14 days). Results: The application of thè spray showed a significant reduction in paìn after only 2 h compared with baseline measurements (P < 0.0001). A progressive reduction of pain through thè 2 weeks was also noted (P < 0.0001). Patient ìesions treated with thè spray also significantly improved after 72 h of treatment both in terms of CRI (P = 0.0186) and as WHO Mucositis score (P < 0.0001). Conclusions and relevance: Although further studies are recommended. our fìndings confimi that spray formulation may offer rapid and effective paìn management aiding a fast mucosal wound healing with consequent improvement of thè ability to eat anc drink which usually compromises patients suffering from OM.

UR - http://hdl.handle.net/10447/73094

UR - http://onlinelibrary.wiley.com/doi/10.1111/odi.2012.18.issue-s1/issuetoc

M3 - Paper

ER -