TY - JOUR
T1 - Effect of mesalazine on epithelial cell proliferation in colonic diverticular disease
AU - Aiello, Fabio
AU - Giorgetti, Gian Marco
AU - Tursi, Antonio
AU - Inchingolo, null
AU - Brandimarte, Giovanni
AU - Elisei, Walter
PY - 2008
Y1 - 2008
N2 - Background and aims: increased epithelial cell proliferation may be detected in diverticular disease, but antibiotics have failed in reducing it. We assess therefore the effect of mesalazine on epithelial cell proliferation in diverticular disease.Methods: a prospective study was conducted on 20 consecutive patients with a new endoscopic diagnosis of symptomatic uncomplicated diverticular disease. The patients were treated with mesalazine 1.6 mg/day for 1 year. The Ki-67 antigen index of the whole crypt and in the upper third was separately evaluated before and after starting the treatment.Results: cell proliferation index was higher in diverticular disease patients than healthy controls both in the whole crypt (median 6.7%, range 2–9% vs. median 1.6%, range 1–3%, p = 0.001) and in the upper third of the crypt (median 6.8%, range 2–8% vs. median 1.8%, range 1–3%, p = 0.001). Cell proliferation decreased throughout the follow-up. In the whole crypt it was 6.7% at entry and 3.8% at the end of treatment (p < 0.005), whereas it was 6.8% at entry and 2.9% at the end of treatment in the upper third of the crypt (p < 0.005).Conclusions: we found mesalazine effective in reducing the colonic cell proliferation in long-term treatment for colonic diverticular disease.
AB - Background and aims: increased epithelial cell proliferation may be detected in diverticular disease, but antibiotics have failed in reducing it. We assess therefore the effect of mesalazine on epithelial cell proliferation in diverticular disease.Methods: a prospective study was conducted on 20 consecutive patients with a new endoscopic diagnosis of symptomatic uncomplicated diverticular disease. The patients were treated with mesalazine 1.6 mg/day for 1 year. The Ki-67 antigen index of the whole crypt and in the upper third was separately evaluated before and after starting the treatment.Results: cell proliferation index was higher in diverticular disease patients than healthy controls both in the whole crypt (median 6.7%, range 2–9% vs. median 1.6%, range 1–3%, p = 0.001) and in the upper third of the crypt (median 6.8%, range 2–8% vs. median 1.8%, range 1–3%, p = 0.001). Cell proliferation decreased throughout the follow-up. In the whole crypt it was 6.7% at entry and 3.8% at the end of treatment (p < 0.005), whereas it was 6.8% at entry and 2.9% at the end of treatment in the upper third of the crypt (p < 0.005).Conclusions: we found mesalazine effective in reducing the colonic cell proliferation in long-term treatment for colonic diverticular disease.
KW - Cell proliferation
KW - colonic mucosa
KW - diverticular disease
KW - mesalazine
KW - treatment
KW - Cell proliferation
KW - colonic mucosa
KW - diverticular disease
KW - mesalazine
KW - treatment
UR - http://hdl.handle.net/10447/47311
M3 - Article
VL - 40
SP - 737
EP - 742
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
ER -