Effect of indoor nitrogen dioxide on lung function in urban environment

Stefania La Grutta, Fabio Cibella, Giuseppina Cuttitta, Gaspare Drago, Roberto Della Maggiore, Simona Panunzi, Silvia Ruggieri, Mario R. Melis, Salvatore Bucchieri, Stefania La Grutta, Andrea De Gaetano, Giovanni Viegi, Silvia Ruggieri

    Risultato della ricerca: Article

    12 Citazioni (Scopus)

    Abstract

    Background: High levels of indoor NO2 are associated with increased asthma symptoms and decreased expiratory peak flows in children. We investigated the association of exposure to domestic indoor NO2, objectively measured in winter and spring, with respiratory symptoms and lung function in a sample of adolescents from a southern Mediterranean area. Methods: From a large school population sample (n=2150) participating in an epidemiological survey in the urban area of the City of Palermo (southern Italy), a sub-sample of 303 adolescents was selected which furnished an enriched sample for cases of current asthma. All subjects were evaluated by a health questionnaire, skin prick tests and spirometry. One-week indoor NO2 monitoring of their homes was performed by diffusive sampling during spring and again during winter. Results: We found that about 25% of subjects were exposed to indoor NO2 levels higher than the 40μg/m3 World Health Organization limit, during both spring and winter. Moreover, subjects exposed to the highest indoor NO2 concentrations had increased frequency of current asthma (p=0.005), wheeze episodes in the last 12 months (p<0.001), chronic phlegm (p=0.013), and rhinoconjunctivitis (p=0.008). Finally, subjects with a personal history of wheeze ever had poorer respiratory function (FEF25-75%, p=0.01) when exposed to higher indoor NO2 concentrations. Conclusions: Home exposure to high indoor NO2 levels frequently occurs in adolescents living in a southern Mediterranean urban area and is significantly associated with the risks for increased frequency of both respiratory symptoms and reduced lung function.
    Lingua originaleEnglish
    pagine (da-a)8-16
    Numero di pagine9
    RivistaEnvironmental Research
    Volume138
    Stato di pubblicazionePublished - 2015

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    Nitrogen Dioxide
    asthma
    nitrogen dioxide
    Asthma
    Lung
    winter
    urban area
    Health
    Spirometry
    World Health Organization
    peak flow
    Skin Tests
    Italy
    skin
    Skin
    Sampling
    Monitoring
    sampling
    monitoring
    history

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Environmental Science(all)

    Cita questo

    La Grutta, S., Cibella, F., Cuttitta, G., Drago, G., Della Maggiore, R., Panunzi, S., ... Ruggieri, S. (2015). Effect of indoor nitrogen dioxide on lung function in urban environment. Environmental Research, 138, 8-16.

    Effect of indoor nitrogen dioxide on lung function in urban environment. / La Grutta, Stefania; Cibella, Fabio; Cuttitta, Giuseppina; Drago, Gaspare; Della Maggiore, Roberto; Panunzi, Simona; Ruggieri, Silvia; Melis, Mario R.; Bucchieri, Salvatore; La Grutta, Stefania; De Gaetano, Andrea; Viegi, Giovanni; Ruggieri, Silvia.

    In: Environmental Research, Vol. 138, 2015, pag. 8-16.

    Risultato della ricerca: Article

    La Grutta, S, Cibella, F, Cuttitta, G, Drago, G, Della Maggiore, R, Panunzi, S, Ruggieri, S, Melis, MR, Bucchieri, S, La Grutta, S, De Gaetano, A, Viegi, G & Ruggieri, S 2015, 'Effect of indoor nitrogen dioxide on lung function in urban environment', Environmental Research, vol. 138, pagg. 8-16.
    La Grutta S, Cibella F, Cuttitta G, Drago G, Della Maggiore R, Panunzi S e altri. Effect of indoor nitrogen dioxide on lung function in urban environment. Environmental Research. 2015;138:8-16.
    La Grutta, Stefania ; Cibella, Fabio ; Cuttitta, Giuseppina ; Drago, Gaspare ; Della Maggiore, Roberto ; Panunzi, Simona ; Ruggieri, Silvia ; Melis, Mario R. ; Bucchieri, Salvatore ; La Grutta, Stefania ; De Gaetano, Andrea ; Viegi, Giovanni ; Ruggieri, Silvia. / Effect of indoor nitrogen dioxide on lung function in urban environment. In: Environmental Research. 2015 ; Vol. 138. pagg. 8-16.
    @article{47c85ea8f0c54305ba71fc1166a60790,
    title = "Effect of indoor nitrogen dioxide on lung function in urban environment",
    abstract = "Background: High levels of indoor NO2 are associated with increased asthma symptoms and decreased expiratory peak flows in children. We investigated the association of exposure to domestic indoor NO2, objectively measured in winter and spring, with respiratory symptoms and lung function in a sample of adolescents from a southern Mediterranean area. Methods: From a large school population sample (n=2150) participating in an epidemiological survey in the urban area of the City of Palermo (southern Italy), a sub-sample of 303 adolescents was selected which furnished an enriched sample for cases of current asthma. All subjects were evaluated by a health questionnaire, skin prick tests and spirometry. One-week indoor NO2 monitoring of their homes was performed by diffusive sampling during spring and again during winter. Results: We found that about 25{\%} of subjects were exposed to indoor NO2 levels higher than the 40μg/m3 World Health Organization limit, during both spring and winter. Moreover, subjects exposed to the highest indoor NO2 concentrations had increased frequency of current asthma (p=0.005), wheeze episodes in the last 12 months (p<0.001), chronic phlegm (p=0.013), and rhinoconjunctivitis (p=0.008). Finally, subjects with a personal history of wheeze ever had poorer respiratory function (FEF25-75{\%}, p=0.01) when exposed to higher indoor NO2 concentrations. Conclusions: Home exposure to high indoor NO2 levels frequently occurs in adolescents living in a southern Mediterranean urban area and is significantly associated with the risks for increased frequency of both respiratory symptoms and reduced lung function.",
    keywords = "2300, Adolescents' health, Biochemistry, Indoor nitrogen dioxide, Questionnaire, Respiratory diseases, Spirometry",
    author = "{La Grutta}, Stefania and Fabio Cibella and Giuseppina Cuttitta and Gaspare Drago and {Della Maggiore}, Roberto and Simona Panunzi and Silvia Ruggieri and Melis, {Mario R.} and Salvatore Bucchieri and {La Grutta}, Stefania and {De Gaetano}, Andrea and Giovanni Viegi and Silvia Ruggieri",
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    T1 - Effect of indoor nitrogen dioxide on lung function in urban environment

    AU - La Grutta, Stefania

    AU - Cibella, Fabio

    AU - Cuttitta, Giuseppina

    AU - Drago, Gaspare

    AU - Della Maggiore, Roberto

    AU - Panunzi, Simona

    AU - Ruggieri, Silvia

    AU - Melis, Mario R.

    AU - Bucchieri, Salvatore

    AU - La Grutta, Stefania

    AU - De Gaetano, Andrea

    AU - Viegi, Giovanni

    AU - Ruggieri, Silvia

    PY - 2015

    Y1 - 2015

    N2 - Background: High levels of indoor NO2 are associated with increased asthma symptoms and decreased expiratory peak flows in children. We investigated the association of exposure to domestic indoor NO2, objectively measured in winter and spring, with respiratory symptoms and lung function in a sample of adolescents from a southern Mediterranean area. Methods: From a large school population sample (n=2150) participating in an epidemiological survey in the urban area of the City of Palermo (southern Italy), a sub-sample of 303 adolescents was selected which furnished an enriched sample for cases of current asthma. All subjects were evaluated by a health questionnaire, skin prick tests and spirometry. One-week indoor NO2 monitoring of their homes was performed by diffusive sampling during spring and again during winter. Results: We found that about 25% of subjects were exposed to indoor NO2 levels higher than the 40μg/m3 World Health Organization limit, during both spring and winter. Moreover, subjects exposed to the highest indoor NO2 concentrations had increased frequency of current asthma (p=0.005), wheeze episodes in the last 12 months (p<0.001), chronic phlegm (p=0.013), and rhinoconjunctivitis (p=0.008). Finally, subjects with a personal history of wheeze ever had poorer respiratory function (FEF25-75%, p=0.01) when exposed to higher indoor NO2 concentrations. Conclusions: Home exposure to high indoor NO2 levels frequently occurs in adolescents living in a southern Mediterranean urban area and is significantly associated with the risks for increased frequency of both respiratory symptoms and reduced lung function.

    AB - Background: High levels of indoor NO2 are associated with increased asthma symptoms and decreased expiratory peak flows in children. We investigated the association of exposure to domestic indoor NO2, objectively measured in winter and spring, with respiratory symptoms and lung function in a sample of adolescents from a southern Mediterranean area. Methods: From a large school population sample (n=2150) participating in an epidemiological survey in the urban area of the City of Palermo (southern Italy), a sub-sample of 303 adolescents was selected which furnished an enriched sample for cases of current asthma. All subjects were evaluated by a health questionnaire, skin prick tests and spirometry. One-week indoor NO2 monitoring of their homes was performed by diffusive sampling during spring and again during winter. Results: We found that about 25% of subjects were exposed to indoor NO2 levels higher than the 40μg/m3 World Health Organization limit, during both spring and winter. Moreover, subjects exposed to the highest indoor NO2 concentrations had increased frequency of current asthma (p=0.005), wheeze episodes in the last 12 months (p<0.001), chronic phlegm (p=0.013), and rhinoconjunctivitis (p=0.008). Finally, subjects with a personal history of wheeze ever had poorer respiratory function (FEF25-75%, p=0.01) when exposed to higher indoor NO2 concentrations. Conclusions: Home exposure to high indoor NO2 levels frequently occurs in adolescents living in a southern Mediterranean urban area and is significantly associated with the risks for increased frequency of both respiratory symptoms and reduced lung function.

    KW - 2300

    KW - Adolescents' health

    KW - Biochemistry

    KW - Indoor nitrogen dioxide

    KW - Questionnaire

    KW - Respiratory diseases

    KW - Spirometry

    UR - http://hdl.handle.net/10447/125023

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    M3 - Article

    VL - 138

    SP - 8

    EP - 16

    JO - Environmental Research

    JF - Environmental Research

    SN - 0013-9351

    ER -