Effect of Exercise on Fatty Acid Metabolism and Adipokine Secretion in Adipose Tissue

Valentina Di Felice, Rosario Barone, Filippo Macaluso, Adriana Mika, Rosario Barone, Tomasz Sledzinski, Valentina Di Felice

Risultato della ricerca: Articlepeer review

26 Citazioni (Scopus)

Abstract

Increased physical activity is an optimal way to maintain a good health. During exercise,triacylglycerols, an energy reservoir in adipose tissue, are hydrolyzed to free fattyacids (FAs) which are then released to the circulation, providing a fuel for workingmuscles. Thus, regular physical activity leads to a reduction of adipose tissue massand improves metabolism. However, the reduction of lipid reservoir is also associatedwith many other interesting changes in adipose tissue FA metabolism. For example, aprolonged exercise contributes to a decrease in lipoprotein lipase activity and resultantreduction of FA uptake. This results in the improvement of mitochondrial function andupregulation of enzymes involved in the metabolism of polyunsaturated fatty acids. Theexercise-induced changes in adipocyte metabolism are associated with modificationsof FA composition. The modifications are adipose tissue depot-specific and followdifferent patterns in visceral and subcutaneous adipose tissue. Moreover, exerciseaffects adipokine release from adipose tissue, and thus, may mitigate inflammation andimprove insulin sensitivity. Another consequence of exercise is the recently describedphenomenon of adipose tissue “beiging,” i.e., a switch from energy-storing whiteadipocyte phenotype to thermogenic FA oxidizing beige adipocytes. This process isregulated by myokines released during the exercise. In this review, we summarizepublished evidence for the exercise-related changes in FA metabolism and adipokinerelease in adipose tissue, and their potential contribution to beneficial cardiovascularand metabolic effects of physical activity
Lingua originaleEnglish
Numero di pagine7
RivistaFrontiers in Physiology
Volume10
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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