Effect of duration of breastfeeding on neuropsychological development at 10 to 12years of age in a cohort of healthy children

Vincenza Tarantino, Barbara De Mei, Patrizia Bisiacchi, Flavia Chiarotti, Stefania Salmaso, Alberto Eugenio Tozzi, Francesco Gesualdo, Vincenza Tarantino, Lidia D'Elia, Mariateresa Romano

Risultato della ricerca: Article

18 Citazioni (Scopus)

Abstract

Aim The aim of this article was to explore the effect of duration of breastfeeding on neurocognitive development. Method The long-term effect of breastfeeding on neurodevelopment was examined through a battery of neuropsychological tests in 1403 children (693 females, 710 males; mean age 11y 9mo [SD 6mo], range: 10y 3mo-12y 8mo) who were originally recruited at 6 to 12weeks of age for a clinical trial on acellular pertussis vaccines. An estimated IQ was obtained from scores of the vocabulary, similarities, block design, and coding tests. Breastfeeding data had been prospectively collected throughout the first year of life. Duration of exclusive breastfeeding was defined as the time during which children received breast milk without receiving any supplemental formula or food. Children were assessed at 10 to 12years of age. We adjusted the analysis on test scores for multiple potential confounders. Results Multivariate analysis showed a significant association between exclusive breastfeeding duration and test scores in the vocabulary (odds ratio [OR] 0.05; confidence interval [CI] 0.00-0.10; p=0.04) and similarities (OR 0.06; CI 0.01-0.11; p=0.03) tests. These associations have a negligible effect size, however. Scores on one writing praxis test subcategory decreased with increasing duration of both exclusive breastfeeding (OR -0.06; CI -0.11 to -0.01; p=0.03) and breastfeeding irrespective of consumption of other foods (OR -0.06; CI -0.11 to -0.01; p=0.03). A negative association was also found between one subcategory of the California verbal learning test and breastfeeding duration longer than 6months (OR -0.21; CI -0.42 to -0.01; p=0.04). Interpretation Breastfed healthy children may perform better on neuropsychological tests in the language domain at 10 to 12years of age. However, the effect of breast milk on neuropsychological performance in healthy children may have a limited clinical relevance and is confounded by parental education. This article is commented on by Latal on page 780 of this issue. © The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.
Lingua originaleEnglish
pagine (da-a)843-848
Numero di pagine6
RivistaDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY
Volume54
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Developmental Neuroscience
  • Pediatrics, Perinatology, and Child Health

Cita questo

Effect of duration of breastfeeding on neuropsychological development at 10 to 12years of age in a cohort of healthy children. / Tarantino, Vincenza; De Mei, Barbara; Bisiacchi, Patrizia; Chiarotti, Flavia; Salmaso, Stefania; Tozzi, Alberto Eugenio; Gesualdo, Francesco; Tarantino, Vincenza; D'Elia, Lidia; Romano, Mariateresa.

In: DEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Vol. 54, 2012, pag. 843-848.

Risultato della ricerca: Article

Tarantino, V, De Mei, B, Bisiacchi, P, Chiarotti, F, Salmaso, S, Tozzi, AE, Gesualdo, F, Tarantino, V, D'Elia, L & Romano, M 2012, 'Effect of duration of breastfeeding on neuropsychological development at 10 to 12years of age in a cohort of healthy children', DEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, vol. 54, pagg. 843-848.
Tarantino, Vincenza ; De Mei, Barbara ; Bisiacchi, Patrizia ; Chiarotti, Flavia ; Salmaso, Stefania ; Tozzi, Alberto Eugenio ; Gesualdo, Francesco ; Tarantino, Vincenza ; D'Elia, Lidia ; Romano, Mariateresa. / Effect of duration of breastfeeding on neuropsychological development at 10 to 12years of age in a cohort of healthy children. In: DEVELOPMENTAL MEDICINE & CHILD NEUROLOGY. 2012 ; Vol. 54. pagg. 843-848.
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title = "Effect of duration of breastfeeding on neuropsychological development at 10 to 12years of age in a cohort of healthy children",
abstract = "Aim The aim of this article was to explore the effect of duration of breastfeeding on neurocognitive development. Method The long-term effect of breastfeeding on neurodevelopment was examined through a battery of neuropsychological tests in 1403 children (693 females, 710 males; mean age 11y 9mo [SD 6mo], range: 10y 3mo-12y 8mo) who were originally recruited at 6 to 12weeks of age for a clinical trial on acellular pertussis vaccines. An estimated IQ was obtained from scores of the vocabulary, similarities, block design, and coding tests. Breastfeeding data had been prospectively collected throughout the first year of life. Duration of exclusive breastfeeding was defined as the time during which children received breast milk without receiving any supplemental formula or food. Children were assessed at 10 to 12years of age. We adjusted the analysis on test scores for multiple potential confounders. Results Multivariate analysis showed a significant association between exclusive breastfeeding duration and test scores in the vocabulary (odds ratio [OR] 0.05; confidence interval [CI] 0.00-0.10; p=0.04) and similarities (OR 0.06; CI 0.01-0.11; p=0.03) tests. These associations have a negligible effect size, however. Scores on one writing praxis test subcategory decreased with increasing duration of both exclusive breastfeeding (OR -0.06; CI -0.11 to -0.01; p=0.03) and breastfeeding irrespective of consumption of other foods (OR -0.06; CI -0.11 to -0.01; p=0.03). A negative association was also found between one subcategory of the California verbal learning test and breastfeeding duration longer than 6months (OR -0.21; CI -0.42 to -0.01; p=0.04). Interpretation Breastfed healthy children may perform better on neuropsychological tests in the language domain at 10 to 12years of age. However, the effect of breast milk on neuropsychological performance in healthy children may have a limited clinical relevance and is confounded by parental education. This article is commented on by Latal on page 780 of this issue. {\circledC} The Authors. Developmental Medicine & Child Neurology {\circledC} 2012 Mac Keith Press.",
author = "Vincenza Tarantino and {De Mei}, Barbara and Patrizia Bisiacchi and Flavia Chiarotti and Stefania Salmaso and Tozzi, {Alberto Eugenio} and Francesco Gesualdo and Vincenza Tarantino and Lidia D'Elia and Mariateresa Romano",
year = "2012",
language = "English",
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pages = "843--848",
journal = "Developmental Medicine and Child Neurology",
issn = "0012-1622",
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TY - JOUR

T1 - Effect of duration of breastfeeding on neuropsychological development at 10 to 12years of age in a cohort of healthy children

AU - Tarantino, Vincenza

AU - De Mei, Barbara

AU - Bisiacchi, Patrizia

AU - Chiarotti, Flavia

AU - Salmaso, Stefania

AU - Tozzi, Alberto Eugenio

AU - Gesualdo, Francesco

AU - Tarantino, Vincenza

AU - D'Elia, Lidia

AU - Romano, Mariateresa

PY - 2012

Y1 - 2012

N2 - Aim The aim of this article was to explore the effect of duration of breastfeeding on neurocognitive development. Method The long-term effect of breastfeeding on neurodevelopment was examined through a battery of neuropsychological tests in 1403 children (693 females, 710 males; mean age 11y 9mo [SD 6mo], range: 10y 3mo-12y 8mo) who were originally recruited at 6 to 12weeks of age for a clinical trial on acellular pertussis vaccines. An estimated IQ was obtained from scores of the vocabulary, similarities, block design, and coding tests. Breastfeeding data had been prospectively collected throughout the first year of life. Duration of exclusive breastfeeding was defined as the time during which children received breast milk without receiving any supplemental formula or food. Children were assessed at 10 to 12years of age. We adjusted the analysis on test scores for multiple potential confounders. Results Multivariate analysis showed a significant association between exclusive breastfeeding duration and test scores in the vocabulary (odds ratio [OR] 0.05; confidence interval [CI] 0.00-0.10; p=0.04) and similarities (OR 0.06; CI 0.01-0.11; p=0.03) tests. These associations have a negligible effect size, however. Scores on one writing praxis test subcategory decreased with increasing duration of both exclusive breastfeeding (OR -0.06; CI -0.11 to -0.01; p=0.03) and breastfeeding irrespective of consumption of other foods (OR -0.06; CI -0.11 to -0.01; p=0.03). A negative association was also found between one subcategory of the California verbal learning test and breastfeeding duration longer than 6months (OR -0.21; CI -0.42 to -0.01; p=0.04). Interpretation Breastfed healthy children may perform better on neuropsychological tests in the language domain at 10 to 12years of age. However, the effect of breast milk on neuropsychological performance in healthy children may have a limited clinical relevance and is confounded by parental education. This article is commented on by Latal on page 780 of this issue. © The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.

AB - Aim The aim of this article was to explore the effect of duration of breastfeeding on neurocognitive development. Method The long-term effect of breastfeeding on neurodevelopment was examined through a battery of neuropsychological tests in 1403 children (693 females, 710 males; mean age 11y 9mo [SD 6mo], range: 10y 3mo-12y 8mo) who were originally recruited at 6 to 12weeks of age for a clinical trial on acellular pertussis vaccines. An estimated IQ was obtained from scores of the vocabulary, similarities, block design, and coding tests. Breastfeeding data had been prospectively collected throughout the first year of life. Duration of exclusive breastfeeding was defined as the time during which children received breast milk without receiving any supplemental formula or food. Children were assessed at 10 to 12years of age. We adjusted the analysis on test scores for multiple potential confounders. Results Multivariate analysis showed a significant association between exclusive breastfeeding duration and test scores in the vocabulary (odds ratio [OR] 0.05; confidence interval [CI] 0.00-0.10; p=0.04) and similarities (OR 0.06; CI 0.01-0.11; p=0.03) tests. These associations have a negligible effect size, however. Scores on one writing praxis test subcategory decreased with increasing duration of both exclusive breastfeeding (OR -0.06; CI -0.11 to -0.01; p=0.03) and breastfeeding irrespective of consumption of other foods (OR -0.06; CI -0.11 to -0.01; p=0.03). A negative association was also found between one subcategory of the California verbal learning test and breastfeeding duration longer than 6months (OR -0.21; CI -0.42 to -0.01; p=0.04). Interpretation Breastfed healthy children may perform better on neuropsychological tests in the language domain at 10 to 12years of age. However, the effect of breast milk on neuropsychological performance in healthy children may have a limited clinical relevance and is confounded by parental education. This article is commented on by Latal on page 780 of this issue. © The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.

UR - http://hdl.handle.net/10447/308477

M3 - Article

VL - 54

SP - 843

EP - 848

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

SN - 0012-1622

ER -