Early Treatment with Zofenopril and Ramipril in Combination with Acetyl Salicylic Acid in Patients with Left Ventricular Systolic Dysfunction after Acute Myocardial Infarction: Results of a 5-Year Follow-up of Patients of the SMILE-4 Study

Salvatore Novo, Giuseppe Ambrosio, Dragos Vinereanu, Stefano Omboni, Ettore Ambrosioni, Claudio Borghi

    Risultato della ricerca: Article

    4 Citazioni (Scopus)

    Abstract

    The SMILE-4 study showed that in patients with left ventricular dysfunction (LVD) after acute myocardial infarction, early treatment with zofenopril plus acetyl salicylic acid is associated with an improved 1-year survival, free from death or hospitalization for cardiovascular (CV) causes, as compared to ramipril plus acetyl salicylic acid. We now report CV outcomes during a 5-year follow-up of the patients of the SMILE-4 study. Three hundred eighty-six of the 518 patients completing the study (51.2%) could be tracked after the study end and 265 could be included in the analysis. During the 5.5 (±2.1) years of follow-up, the primary endpoint occurred in 27.8% of patients originally randomized and treated with zofenopril and in 43.8% of patients treated with ramipril [odds ratio (OR) and 95% confidence interval, 0.65 (0.43-0.98), P = 0.041]. Such a result was achieved through a significantly larger reduction in CV hospitalization under zofenopril [OR: 0.61 (0.37-0.99), P = 0.047], whereas reduction in mortality rate with zofenopril did not achieve statistical significance versus ramipril [OR: 0.75 (0.36-1.59), P = 0.459]. These results were in line with those achieved during the initial 1-year follow-up. Benefits of early treatment of patients with LVD after acute myocardial infarction with zofenopril are sustained over many years as compared to ramipril.
    Lingua originaleEnglish
    pagine (da-a)298-304
    Numero di pagine7
    RivistaJournal of Cardiovascular Pharmacology
    Volume69
    Stato di pubblicazionePublished - 2017

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Cardiology and Cardiovascular Medicine

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