E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines

Sorrentino, M.; Matranga, D.; Grisafi, F.; Scoarughi, G.; Barbato, G.; Guarini, A.

Risultato della ricerca: Paper

Abstract

Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have an encouraging effect in inducing a transient pore formation through cellular membranes. This permeability condition has been demonstrated to be useful in enhancing gene and drug delivery. Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinical practice. One of the main limits in the analysis of circulating tumor DNA is the low concentration rate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated to be effective for the release of specific circulating tumor biomarkers in many mouse models. We demonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLC without inducing any apoptotic or necrotic event.
Lingua originaleEnglish
Stato di pubblicazionePublished - 2017

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Cell Line
DNA
Body Fluids
Tumor Biomarkers
Nucleic Acids
Neoplasms
Biopsy
Membranes
Pharmaceutical Preparations
Genes
Ultrasonic Waves

Cita questo

Sorrentino, M.; Matranga, D.; Grisafi, F.; Scoarughi, G.; Barbato, G.; Guarini, A. (2017). E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines.

E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines. / Sorrentino, M.; Matranga, D.; Grisafi, F.; Scoarughi, G.; Barbato, G.; Guarini, A.

2017.

Risultato della ricerca: Paper

Sorrentino, M.; Matranga, D.; Grisafi, F.; Scoarughi, G.; Barbato, G.; Guarini, A. 2017, 'E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines'.
Sorrentino, M.; Matranga, D.; Grisafi, F.; Scoarughi, G.; Barbato, G.; Guarini, A.. E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines. 2017.
Sorrentino, M.; Matranga, D.; Grisafi, F.; Scoarughi, G.; Barbato, G.; Guarini, A. / E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines.
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title = "E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines",
abstract = "Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have an encouraging effect in inducing a transient pore formation through cellular membranes. This permeability condition has been demonstrated to be useful in enhancing gene and drug delivery. Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinical practice. One of the main limits in the analysis of circulating tumor DNA is the low concentration rate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated to be effective for the release of specific circulating tumor biomarkers in many mouse models. We demonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLC without inducing any apoptotic or necrotic event.",
author = "{Sorrentino, M.; Matranga, D.; Grisafi, F.; Scoarughi, G.; Barbato, G.; Guarini, A.} and Antonio Russo and {Di Piazza}, Florinda and Valentina Calo' and {Di Stefano}, {Anna Barbara} and Lavinia Insalaco and Marta Castiglia and Cristiano Corso and Enrico Bronte and Daniela Massihnia and Nadia Barraco and Alessandro Perez and Luisa Castellana and Angela Listi'",
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TY - CONF

T1 - E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines

AU - Sorrentino, M.; Matranga, D.; Grisafi, F.; Scoarughi, G.; Barbato, G.; Guarini, A.

AU - Russo, Antonio

AU - Di Piazza, Florinda

AU - Calo', Valentina

AU - Di Stefano, Anna Barbara

AU - Insalaco, Lavinia

AU - Castiglia, Marta

AU - Corso, Cristiano

AU - Bronte, Enrico

AU - Massihnia, Daniela

AU - Barraco, Nadia

AU - Perez, Alessandro

AU - Castellana, Luisa

AU - Listi', Angela

PY - 2017

Y1 - 2017

N2 - Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have an encouraging effect in inducing a transient pore formation through cellular membranes. This permeability condition has been demonstrated to be useful in enhancing gene and drug delivery. Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinical practice. One of the main limits in the analysis of circulating tumor DNA is the low concentration rate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated to be effective for the release of specific circulating tumor biomarkers in many mouse models. We demonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLC without inducing any apoptotic or necrotic event.

AB - Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have an encouraging effect in inducing a transient pore formation through cellular membranes. This permeability condition has been demonstrated to be useful in enhancing gene and drug delivery. Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinical practice. One of the main limits in the analysis of circulating tumor DNA is the low concentration rate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated to be effective for the release of specific circulating tumor biomarkers in many mouse models. We demonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLC without inducing any apoptotic or necrotic event.

UR - http://hdl.handle.net/10447/245240

M3 - Paper

ER -