Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have anencouraging effect in inducing a transient pore formation through cellular membranes. Thispermeability condition has been demonstrated to be useful in enhancing gene and drug delivery.Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinicalpractice. One of the main limits in the analysis of circulating tumor DNA is the low concentrationrate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated tobe effective for the release of specific circulating tumor biomarkers in many mouse models. Wedemonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLCwithout inducing any apoptotic or necrotic event.
|Numero di pagine||0|
|Stato di pubblicazione||Published - 2017|
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