E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines

Risultato della ricerca: Other

Abstract

Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have anencouraging effect in inducing a transient pore formation through cellular membranes. Thispermeability condition has been demonstrated to be useful in enhancing gene and drug delivery.Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinicalpractice. One of the main limits in the analysis of circulating tumor DNA is the low concentrationrate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated tobe effective for the release of specific circulating tumor biomarkers in many mouse models. Wedemonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLCwithout inducing any apoptotic or necrotic event.
Lingua originaleEnglish
Numero di pagine0
Stato di pubblicazionePublished - 2017

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Cell Line
DNA
Body Fluids
Tumor Biomarkers
Nucleic Acids
Neoplasms
Biopsy
Membranes
Pharmaceutical Preparations
Genes
Ultrasonic Waves

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@conference{35ef1729e9a143a9a0621693c336a81e,
title = "E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines",
abstract = "Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have anencouraging effect in inducing a transient pore formation through cellular membranes. Thispermeability condition has been demonstrated to be useful in enhancing gene and drug delivery.Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinicalpractice. One of the main limits in the analysis of circulating tumor DNA is the low concentrationrate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated tobe effective for the release of specific circulating tumor biomarkers in many mouse models. Wedemonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLCwithout inducing any apoptotic or necrotic event.",
author = "Alessandro Perez and Valentina Calo' and Daniela Massihnia and {Di Stefano}, {Anna Barbara} and Cristiano Corso and Marta Castiglia and Antonio Russo and Angela Listi' and Nadia Barraco and Enrico Bronte and {Di Piazza}, Florinda and Lavinia Insalaco and Luisa Castellana",
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language = "English",

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TY - CONF

T1 - E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines

AU - Perez, Alessandro

AU - Calo', Valentina

AU - Massihnia, Daniela

AU - Di Stefano, Anna Barbara

AU - Corso, Cristiano

AU - Castiglia, Marta

AU - Russo, Antonio

AU - Listi', Angela

AU - Barraco, Nadia

AU - Bronte, Enrico

AU - Di Piazza, Florinda

AU - Insalaco, Lavinia

AU - Castellana, Luisa

PY - 2017

Y1 - 2017

N2 - Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have anencouraging effect in inducing a transient pore formation through cellular membranes. Thispermeability condition has been demonstrated to be useful in enhancing gene and drug delivery.Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinicalpractice. One of the main limits in the analysis of circulating tumor DNA is the low concentrationrate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated tobe effective for the release of specific circulating tumor biomarkers in many mouse models. Wedemonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLCwithout inducing any apoptotic or necrotic event.

AB - Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have anencouraging effect in inducing a transient pore formation through cellular membranes. Thispermeability condition has been demonstrated to be useful in enhancing gene and drug delivery.Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinicalpractice. One of the main limits in the analysis of circulating tumor DNA is the low concentrationrate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated tobe effective for the release of specific circulating tumor biomarkers in many mouse models. Wedemonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLCwithout inducing any apoptotic or necrotic event.

UR - http://hdl.handle.net/10447/245240

M3 - Other

ER -