E26The effects of LIPUS on ctDNA release in the medium of NSCLC cell lines

Marta Castiglia, Angela Listi', Valentina Calo', Daniela Massihnia, Anna Barbara Di Stefano, Antonio Russo, Alessandro Perez, Cristiano Corso, Nadia Barraco, Di Piazza, Insalaco, Marta Castiglia, Bronte, Listì, Barraco, Daniela Massihnia, Perez, Guarini, Grisafi, CastellanaRusso, Gaetano Barbato, Cristiano Corso, Sorrentino, Di Stefano, Scoarughi, Calò, Domenica Matranga, Enrico Bronte, Florinda Di Piazza, Lavinia Insalaco, Luisa Castellana

Risultato della ricerca: Otherpeer review

Abstract

Low Intensity Pulsed Ultrasound (LIPUS) application has been shown to have anencouraging effect in inducing a transient pore formation through cellular membranes. Thispermeability condition has been demonstrated to be useful in enhancing gene and drug delivery.Nowadays, in the management of NSCLC patients, the use of liquid biopsy has entered the clinicalpractice. One of the main limits in the analysis of circulating tumor DNA is the low concentrationrate of nucleic acids in body fluids. Ultrasound stimulation (US) has been recently demonstrated tobe effective for the release of specific circulating tumor biomarkers in many mouse models. Wedemonstrated the role of US in inducing the release of tumor DNA fragments (rtDNA) in NSCLCwithout inducing any apoptotic or necrotic event.
Lingua originaleEnglish
Numero di pagine0
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

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