E-PTFE (Gore-Tex) implant with or without low-dosage mitomycin-C as an adjuvantin penetrating glaucoma surgery: 2 year randomized clinical trial.

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21 Citazioni (Scopus)

Abstract

Purpose: To test the expanded polytetrafluoroethylene (ePTFE) as a new adjuvantin trabeculectomy.Methods: Consecutive glaucoma surgical inpatients were observed at the Department of Ophthalmology of Palermo University. Sixty patients (60 eyes)were randomly assigned to undergo trabeculectomy (T), trabeculectomy withmitomycin-C (TMMC), with ePTFE (TG) or with mitomycin-C and ePTFE (TGMMC). Postoperative visits were scheduled at 24 hr, 7 days, 1, 3, 6, 12, 18 and 24 months. Complete success and qualified success were assessed at two target intraocular pressure (IOP) levels – £21 and £17 mmHg – by Kaplan–Meier curves.Results: The postoperative IOP reduction was significant (P < 0.01) at the endpoint in all groups, with a mean IOP of 16.9 (±2.9), 16.2 (±2.7), 15.3 (±3.4) and 15.2 (±4.3) mmHg in T, TMMC, TG and TGMMC eyes, respectively. No intergroup difference was found at either IOP targets. The Kaplan–Meier curves relating to either the £21 mmHg or the £17 mmHg targetIOP did not show significant intergroup differences for complete and qualifiedsuccess rate. When ePTFE was used, a trend favouring the medium-term survival rate was noted. No adverse reaction to the ePTFE was present, and no membrane extrusion or conjuctival erosion were noted in any cases. Hypotony was significantly more frequent (P = 0.035) in groups without ePTFE.Moreover, the late MMC-related complications were more frequent when MMC was applied.Conclusion: Expanded polytetrafluoroethylene implant in trabeculectomy is well tolerated and could act as a filtration modulating device. Therefore, it is useful in reducing early hypotony-related complications and contributes to attaining medium-term IOP control that is comparable to the low-dosage MMC.
Lingua originaleEnglish
pagine (da-a)314-321
Numero di pagine8
RivistaActa Ophthalmologica
Volume86
Stato di pubblicazionePublished - 2008

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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