Dynamical properties of water in living cells

Antonio Cupane, Irina Piazza, Miguel A. Gonzalez, Irina Piazza, Francesca Natali, Emmanuel L. Barbier, Jacques Ollivier, Nora Collomb, Claire Rome

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

With the aim of studying the effect of water dynamics on the properties of biological systems, in this paper, we present a quasi-elastic neutron scattering study on three different types of living cells, differing both in their morphological and tumor properties. The measured scattering signal, which essentially originates from hydrogen atoms present in the investigated systems, has been analyzed using a global fitting strategy using an optimized theoretical model that considers various classes of hydrogen atoms and allows disentangling diffusive and rotational motions. The approach has been carefully validated by checking the reliability of the calculation of parameters and their 99% confidence intervals. We demonstrate that quasi-elastic neutron scattering is a suitable experimental technique to characterize the dynamics of intracellular water in the angstrom/picosecond space/time scale and to investigate the effect of water dynamics on cellular biodiversity.
Lingua originaleEnglish
Numero di pagine0
RivistaFrontiers of Physics
Volume13
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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