Dupuytren's contracture: an update of biomolecular aspects and therapeutic perspectives

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Abstract

The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren's contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren's disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.
Lingua originaleEnglish
pagine (da-a)557-562
Numero di pagine6
RivistaJournal of Hand Surgery
Volume30
Stato di pubblicazionePublished - 2005

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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