Dupuytren's contracture: an update of biomolecular aspects and therapeutic perspectives

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Abstract

The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren's contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren's disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.
Lingua originaleEnglish
pagine (da-a)557-562
Numero di pagine6
RivistaJournal of Hand Surgery
Volume30
Stato di pubblicazionePublished - 2005

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Dupuytren Contracture
Myofibroblasts
Fascia
Extracellular Matrix
Therapeutics
Fibroblasts
Cytokines
Growth

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cita questo

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title = "Dupuytren's contracture: an update of biomolecular aspects and therapeutic perspectives",
abstract = "The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren's contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren's disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.",
keywords = "GROWTH-FACTOR-BETA; GENETIC SUSCEPTIBILITY; NONOPERATIVE TREATMENT; DISEASE; COLLAGEN; FIBRONECTIN; ASSOCIATION; STEROIDS; FIBROSIS; MATRIX",
author = "Francesco Moschella and Adriana Cordova and Bartolo Corradino and Massimiliano Tripoli",
year = "2005",
language = "English",
volume = "30",
pages = "557--562",
journal = "Journal of Hand Surgery",
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T1 - Dupuytren's contracture: an update of biomolecular aspects and therapeutic perspectives

AU - Moschella, Francesco

AU - Cordova, Adriana

AU - Corradino, Bartolo

AU - Tripoli, Massimiliano

PY - 2005

Y1 - 2005

N2 - The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren's contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren's disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.

AB - The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren's contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren's disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.

KW - GROWTH-FACTOR-BETA; GENETIC SUSCEPTIBILITY; NONOPERATIVE TREATMENT; DISEASE; COLLAGEN; FIBRONECTIN; ASSOCIATION; STEROIDS; FIBROSIS; MATRIX

UR - http://hdl.handle.net/10447/2968

M3 - Article

VL - 30

SP - 557

EP - 562

JO - Journal of Hand Surgery

JF - Journal of Hand Surgery

SN - 0266-7681

ER -