Drug release from α,β-poly(N-2-hydroxyethyl)-DL-aspartamide based microparticles

Giovanna Pitarresi, Gaetano Giammona, Rita Muzzalupo, Picci, Iemma, Paola Pierro

Risultato della ricerca: Articlepeer review

31 Citazioni (Scopus)

Abstract

Spherical pH-sensitive microparticles have been prepared by reverse phase suspension polymerization technique. Starting polymerhas been alpha,beta-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) partially derivatized with glycidylmethacrylate (GMA). PHEAGMAcopolymer (PHG) has been crosslinked in the presence of acrylic acid (AA) or methacrylic acid (MA) at variousconcentration. The obtained microparticles have been characterized by FT-IR spectrophotometry, particle size distribution analysisand scanning electron microscopy. In order to have information about water affinity of the prepared samples, swellingmeasurements have been carried out in aqueous media which simulate some biological fluids. The possibility to employ the preparedsamples as pH-sensitive microparticles has been investigated by performing in vitro release studies. Experimental data have showedthat the release rate from these microparticles depends on the environmental pH and the chemical structure of the drug.
Lingua originaleEnglish
pagine (da-a)4333-4343
Numero di pagine11
RivistaBiomaterials
Volume25
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2500.2503???
  • ???subjectarea.asjc.1300.1304???
  • ???subjectarea.asjc.2500.2502???
  • ???subjectarea.asjc.2200.2211???

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