DRUG DELIVERY FROM MUCOADHESIVE DISKS BASED ON A PHOTO-CROSS-LINKABLE POLYASPARTAMIDE DERIVATIVE

Giovanna Pitarresi, Gaetano Giammona, Giuseppe Tripodo, Paola Pierro

Risultato della ricerca: Articlepeer review

11 Citazioni (Scopus)

Abstract

Disks for local delivery of amoxicillin to the buccal or gastric cavity were prepared using as starting polymer a polyaspartamide derivative. In particular, α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) was derivatized with glycidyl methacrylate (GMA) in order to synthesize PHG, a photo-cross-linkable and biodegradable polymer that gives rise to the formation of a chemical hydrogel (PHG-UV) by UV irradiation. This hydrogel was shaped as disks whose mucoadhesive properties have been confirmed by swelling measurements in phosphate buffer/citric acid solution at pH 7.0 in the presence of various concentrations of mucin. Swelling ability of PHG-UV disks was also evaluated in simulated salivary and gastric fluids. Amoxicillin was soaked into PHG-UV disks and its release was evaluated in simulated buccal and gastric conditions. The results obtained showed that the prepared disks also provide a reduction of the drug degradation in acidic medium.
Lingua originaleEnglish
pagine (da-a)377-382
Numero di pagine6
RivistaJournal of Drug Delivery Science and Technology
Volume15
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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