Double-Network-Structured Graphene Oxide-Containing Nanogels as Photothermal Agents for the Treatment of Colorectal Cancer

Risultato della ricerca: Article

17 Citazioni (Scopus)

Abstract

Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the huge aromatic surface area, allows to easily load high amount of irinotecan (33.0% w/w) and confers to the system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that the release of antitumor drug is influenced both by the pH of the external medium and the NIR irradiation process. In vitro biological studies, conducted on human colon cancer cells (HCT 116), revealed that nanogels are uptaken by the cancer cells and, in the presence of the antitumor drug, can produce a synergistic hyperthermic/cytotoxic effect. Finally, 3D experiments demonstrate that it is possible to conduct thermal ablation of solid tumors after the intratumoral administration of nanogels.
Lingua originaleEnglish
pagine (da-a)1010-1018
Numero di pagine9
RivistaBiomacromolecules
Volume18
Stato di pubblicazionePublished - 2017

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Graphite
Oxides
Graphene
irinotecan
Cells
Hyaluronic acid
Antineoplastic Agents
Infrared lasers
Ablation
Laser beams
Tumors
Irradiation
Hyaluronic Acid
Infrared radiation
Experiments
NanoGel
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cita questo

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title = "Double-Network-Structured Graphene Oxide-Containing Nanogels as Photothermal Agents for the Treatment of Colorectal Cancer",
abstract = "Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the huge aromatic surface area, allows to easily load high amount of irinotecan (33.0{\%} w/w) and confers to the system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that the release of antitumor drug is influenced both by the pH of the external medium and the NIR irradiation process. In vitro biological studies, conducted on human colon cancer cells (HCT 116), revealed that nanogels are uptaken by the cancer cells and, in the presence of the antitumor drug, can produce a synergistic hyperthermic/cytotoxic effect. Finally, 3D experiments demonstrate that it is possible to conduct thermal ablation of solid tumors after the intratumoral administration of nanogels.",
author = "Palumbo, {Fabio Salvatore} and Nicol{\`o} Mauro and Calogero Fiorica and Cinzia Scialabba and Giovanna Pitarresi and Gaetano Giammona and Gaetano Giammona",
year = "2017",
language = "English",
volume = "18",
pages = "1010--1018",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",

}

TY - JOUR

T1 - Double-Network-Structured Graphene Oxide-Containing Nanogels as Photothermal Agents for the Treatment of Colorectal Cancer

AU - Palumbo, Fabio Salvatore

AU - Mauro, Nicolò

AU - Fiorica, Calogero

AU - Scialabba, Cinzia

AU - Pitarresi, Giovanna

AU - Giammona, Gaetano

AU - Giammona, Gaetano

PY - 2017

Y1 - 2017

N2 - Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the huge aromatic surface area, allows to easily load high amount of irinotecan (33.0% w/w) and confers to the system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that the release of antitumor drug is influenced both by the pH of the external medium and the NIR irradiation process. In vitro biological studies, conducted on human colon cancer cells (HCT 116), revealed that nanogels are uptaken by the cancer cells and, in the presence of the antitumor drug, can produce a synergistic hyperthermic/cytotoxic effect. Finally, 3D experiments demonstrate that it is possible to conduct thermal ablation of solid tumors after the intratumoral administration of nanogels.

AB - Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the huge aromatic surface area, allows to easily load high amount of irinotecan (33.0% w/w) and confers to the system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that the release of antitumor drug is influenced both by the pH of the external medium and the NIR irradiation process. In vitro biological studies, conducted on human colon cancer cells (HCT 116), revealed that nanogels are uptaken by the cancer cells and, in the presence of the antitumor drug, can produce a synergistic hyperthermic/cytotoxic effect. Finally, 3D experiments demonstrate that it is possible to conduct thermal ablation of solid tumors after the intratumoral administration of nanogels.

UR - http://hdl.handle.net/10447/222194

M3 - Article

VL - 18

SP - 1010

EP - 1018

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

ER -