Abstract

Introduction. The incidence of cancer compared for age groups is 3–4 times higher in transplant recipients than the general population. The increased risk is related toimmunosuppressive therapy as well as the use of increasingly older donors and recipients.Although cardiovascular disease with a functioning transplant is the leading cause of death (47%), cancer mortality is significant especially among older patients. However, the most frequent posttransplantation cancers relate to hemolymphopoietic organs and skin,whereas the occurrence of solid tumors elsewhere is rare. Herein we have described a rare case of synchronous double malignancy of endocrine organs (thyroid-adrenal) in a young woman who underwent renal transplantation.Case Report. A 37-year-old woman with end-stage renal disease for 18 yearsunderwent transplantation when she was 30 years old with a 17-year-old standardcadaveric donor receiving immunosuppressive therapy with mycophenolate mofetil,cyclosporine, and steroids. Follow-up demonstrated good indices of renal function with negative tumor pathology at 79 months when, at an annual ultrasound monitoring, wefound a lesion in the right lobe of the thyroid and left adrenal neoplasm of dubiousinterpretation. The cytology for the thyroid was highly suspicious of papillarycarcinoma, whereas the histological examination after surgery diagnosed a thyroidmultifocal papillary microcarcinoma (mpT1NxMx) and an oxyphil cell adrenocorticalcarcinoma (pT2, N0).Results. Six months after total thyroidectomy with central lymphadenectomy and left kidney and adrenal gland removal the patient showed no evidence of recurrent lesions and stable graft function.Conclusions. The rare occurrence of solid tumors after transplantation has no knownetiopathogenetic relation. Despite the young age of the patient and the double neoplasmthat could have produced an unfavorable outcome for the patient and the graft, careful follow-up for tumor pathologies and multidisciplinary management achieved an early diagnosis of both tumors with a surgical eradication without adjuvant therapy, preserving the life of the patient and the function of the graft.
Lingua originaleEnglish
pagine (da-a)1201-1205
Numero di pagine5
RivistaTransplantation Proceedings
Volume43
Stato di pubblicazionePublished - 2011

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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