Does metformin induce ovulation in normoandrogenic anovulatory women?

Enrico Carmina, Rogerio A. Lobo

Risultato della ricerca: Articlepeer review

18 Citazioni (Scopus)


Objective:This study was undertaken to evaluate the efficacy of metformin in women with anovulation who do not have evidence for hyperandrogenism and classic polycystic ovary syndrome.Study design:A randomized trial of metformin (1500 mg daily) and placebo in 24 anovulatory women was undertaken for 3 months. Assessments of changes in hormone levels and insulin sensitivity were carried out. Abnormal ormonal values were defined by levels exceeding the range in normal ovulatory controls.Results:Anovulatory women had normal androgen levels and luteinizing hormone but had higher serum insulin and lower insulin sensitivity compared with controls. Over 3 months, there were 16 ovulatory cycles with metformin and only 4 with placebo (P<.05). Success of ovulation did not correlate with changes in androgen, insulin, or insulin sensitivity parameters.Conclusion:Metformin may be useful for inducing ovulation in anovulatory women who do not have hyperandrogenism. This effect may be independent of a lowering of androgen or insulin levels
Lingua originaleEnglish
pagine (da-a)1580-1584
Numero di pagine5
RivistaAmerican Journal of Obstetrics and Gynecology
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

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