Do GOLD stages of COPD severity really correspond to differences in health status?

Vincenzo Bellia, Nicola Scichilone, Vittorio Grassi, Comel, Cantatore, Riccardo Pistelli, Masotti, Trabucchi, Trabucchi, Caione, Zuccaro, Galetti, Carnevale, Pinelli, Goria, Franco Rengo, Arnone, Palleschi, Valerio, CorradiDe Angelis S., Melillo, Melillo, Angelini, Costelli, Flora, Marchetti, Pisacreta, Caione, Torres, Barbera, Stefania Maggi, Bellotti, Valerio, Grassi, Semeraro, Mugeri, La Chiara, Grumelli, Lo Nardo, Tiozzo, Battiloro, Cieri, Tansella, Consales, Dalla Montà, Simona Zacchei, Noya, Guerini, Mesto, Torriglia, Iraldi, Casarotti, Agretti, Guerini, Cossi, Peruzza, Fantoni, Venezia, Gaudiosi, Alessandria, Cilla, Melisenda Chiarlone, Bocchino, Camilli, Zuccaro, Fea, Palleschi, Claudio Imperiale, Semeraro, Savia, Albanese, Vetta, Ranieri, Pedone, Barbisoni, Palleschi, Daniela Matteuzzi, Cacciatore, Palummeri, Paggi, Giusti, Luciano Motta, Senin, Calabrese, De Martinis, Olivieri, Olivieri, Abete, Raffaele Antonelli-Incalzi, Grassi, Capurso, Calabrese, Melillo, Pini, Peretti, Enzi, Giulio Masotti, Franco Rengo, Anni, Barbarito, Argentieri

Risultato della ricerca: Article

129 Citazioni (Scopus)

Abstract

The purpose of this study was to assess whether different stages of chronic obstructive pulmonary disease (COPD) severity defined according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria correlate with meaningful differences in health status. A total of 381 COPD patients, aged 73+/-6 yrs, were classified in the five GOLD stages. Disease-specific (St George Respiratory Questionnaire (SGRQ)) and generic indexes of health status were measured in all patients. Multivariate analysis of covariance or Kruskal Wallis tests were used to compare health status indexes across the spectrum of GOLD stages of COPD severity. GOLD stages of COPD severity significantly differed in SGRQ components and Barthel's index, but not in the indexes assessing cognitive and affective status and quality of sleep. The largest variation in health status was observed at the transition from stage IIa to stage IIb, while there were no other significant differences between consecutive stages. Both female sex and comorbidity were associated with a greater impact of COPD on the health status. In conclusion, the upper limit of stage IIb (forced expiratory volume in one second of 49%) marks a threshold for dramatic worsening of health status. Progression of chronic obstructive pulmonary disease severity from stage 0 to stage IIa does not correspond to any meaningful difference in health status.
Lingua originaleEnglish
pagine (da-a)444-9-
Numero di pagine6
RivistaEuropean Respiratory Journal
Volume22
Stato di pubblicazionePublished - 2003

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cita questo

Bellia, V., Scichilone, N., Grassi, V., Comel, Cantatore, Pistelli, R., Masotti, Trabucchi, Trabucchi, Caione, Zuccaro, Galetti, Carnevale, Pinelli, Goria, Rengo, F., Arnone, Palleschi, Valerio, ... Argentieri (2003). Do GOLD stages of COPD severity really correspond to differences in health status? European Respiratory Journal, 22, 444-9-.