TY - JOUR
T1 - DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol
AU - Cappello, Francesco
AU - Gorzynik, Monika
AU - Marino Gammazza, Antonella
AU - Gammazza, Antonella Marino
AU - Daca, Agnieszka
AU - Kuban-Jankowska, Alicja
AU - Rzeszutek, Iwona
AU - Gorska, Magdalena
AU - Gorzynik, Monika
AU - Wnuk, Maciej
AU - Gorska, Magdalena
AU - Lewinska, Anna
AU - Cappello, Francesco
AU - Wozniak, Michal
AU - Zmijewski, Michal
PY - 2015
Y1 - 2015
N2 - 2-Methoxyestradiol (2-ME) is a physiological metabolite of 17β-estradiol. At pharmacological concentrations, 2-ME inhibits colon, breast and lung cancer in tumor models. Here we investigated the effect of physiologically relevant concentrations of 2-ME in osteosarcoma cell model. We demonstrated that 2-ME increased nuclear localization of neuronal nitric oxide synthase, resulting in nitro-oxidative DNA damage. This in turn caused cell cycle arrest and apoptosis in osteosarcoma cells. We suggest that 2-ME is a naturally occurring hormone with potential anti-cancer properties.
AB - 2-Methoxyestradiol (2-ME) is a physiological metabolite of 17β-estradiol. At pharmacological concentrations, 2-ME inhibits colon, breast and lung cancer in tumor models. Here we investigated the effect of physiologically relevant concentrations of 2-ME in osteosarcoma cell model. We demonstrated that 2-ME increased nuclear localization of neuronal nitric oxide synthase, resulting in nitro-oxidative DNA damage. This in turn caused cell cycle arrest and apoptosis in osteosarcoma cells. We suggest that 2-ME is a naturally occurring hormone with potential anti-cancer properties.
UR - http://hdl.handle.net/10447/206129
UR - http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=3913&path%5B%5D=8752
M3 - Article
SN - 1949-2553
VL - 6
SP - 15449
EP - 15463
JO - Oncotarget
JF - Oncotarget
ER -