DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol

Francesco Cappello, Monika Gorzynik, Antonella Marino Gammazza, Antonella Marino Gammazza, Agnieszka Daca, Alicja Kuban-Jankowska, Iwona Rzeszutek, Magdalena Gorska, Monika Gorzynik, Maciej Wnuk, Magdalena Gorska, Anna Lewinska, Francesco Cappello, Michal Wozniak, Michal Zmijewski

Risultato della ricerca: Articlepeer review

19 Citazioni (Scopus)

Abstract

2-Methoxyestradiol (2-ME) is a physiological metabolite of 17β-estradiol. At pharmacological concentrations, 2-ME inhibits colon, breast and lung cancer in tumor models. Here we investigated the effect of physiologically relevant concentrations of 2-ME in osteosarcoma cell model. We demonstrated that 2-ME increased nuclear localization of neuronal nitric oxide synthase, resulting in nitro-oxidative DNA damage. This in turn caused cell cycle arrest and apoptosis in osteosarcoma cells. We suggest that 2-ME is a naturally occurring hormone with potential anti-cancer properties.
Lingua originaleEnglish
pagine (da-a)15449-15463
Numero di pagine15
RivistaOncotarget
Volume6
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2730???

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