DNA combinatorial messages and Epigenomics: The case of chromatin organization and nucleosome occupancy in eukaryotic genomes

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Abstract

Epigenomics is the study of modifications on the genetic material of a cell that do not depend on changes in the DNA sequence, since those latter involve specific proteins around which DNA wraps. The end result is that Epigenomic changes have a fundamental role in the proper working of each cell in Eukaryotic organisms. A particularly important part of Epigenomics concentrates on the study of chromatin, that is, a fiber composed of a DNA-protein complex and very characterizing of Eukaryotes. Understanding how chromatin is assembled and how it changes is fundamental for Biology. In more than thirty years of research in this area, Mathematics and Theoretical Computer Science have gained a prominent role, in terms of modeling and mining, regarding in particular the so-called 10 nm fiber. Starting from some very basic notions of Biology, we briefly illustrate the recent advances obtained via laboratory experiments on the organization and dynamics of chromatin. Then, we mainly concentrate our attention on the contributions given by Combinatorial and Informational Methodologies, that are at the hearth of Theoretical Computer Science, to the understanding of mechanisms determining the 10 nm fiber. We conclude highlighting several directions of investigation that are perceived as important and where Theoretical Computer Science can provide high impact results
Lingua originaleEnglish
pagine (da-a)117-130
Numero di pagine14
RivistaTheoretical Computer Science
Volume792
Stato di pubblicazionePublished - 2019

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Chromatin
Computer science
Computer Science
Genome
DNA
Genes
Fiber
Biology
Fibers
Proteins
Protein
DNA sequences
Cell
DNA Sequence
Mining
Methodology
Modeling
Experiment
Experiments

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

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title = "DNA combinatorial messages and Epigenomics: The case of chromatin organization and nucleosome occupancy in eukaryotic genomes",
abstract = "Epigenomics is the study of modifications on the genetic material of a cell that do not depend on changes in the DNA sequence, since those latter involve specific proteins around which DNA wraps. The end result is that Epigenomic changes have a fundamental role in the proper working of each cell in Eukaryotic organisms. A particularly important part of Epigenomics concentrates on the study of chromatin, that is, a fiber composed of a DNA-protein complex and very characterizing of Eukaryotes. Understanding how chromatin is assembled and how it changes is fundamental for Biology. In more than thirty years of research in this area, Mathematics and Theoretical Computer Science have gained a prominent role, in terms of modeling and mining, regarding in particular the so-called 10 nm fiber. Starting from some very basic notions of Biology, we briefly illustrate the recent advances obtained via laboratory experiments on the organization and dynamics of chromatin. Then, we mainly concentrate our attention on the contributions given by Combinatorial and Informational Methodologies, that are at the hearth of Theoretical Computer Science, to the understanding of mechanisms determining the 10 nm fiber. We conclude highlighting several directions of investigation that are perceived as important and where Theoretical Computer Science can provide high impact results",
author = "Raffaele Giancarlo and Rombo, {Simona Ester} and Filippo Utro",
year = "2019",
language = "English",
volume = "792",
pages = "117--130",
journal = "Theoretical Computer Science",
issn = "0304-3975",
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TY - JOUR

T1 - DNA combinatorial messages and Epigenomics: The case of chromatin organization and nucleosome occupancy in eukaryotic genomes

AU - Giancarlo, Raffaele

AU - Rombo, Simona Ester

AU - Utro, Filippo

PY - 2019

Y1 - 2019

N2 - Epigenomics is the study of modifications on the genetic material of a cell that do not depend on changes in the DNA sequence, since those latter involve specific proteins around which DNA wraps. The end result is that Epigenomic changes have a fundamental role in the proper working of each cell in Eukaryotic organisms. A particularly important part of Epigenomics concentrates on the study of chromatin, that is, a fiber composed of a DNA-protein complex and very characterizing of Eukaryotes. Understanding how chromatin is assembled and how it changes is fundamental for Biology. In more than thirty years of research in this area, Mathematics and Theoretical Computer Science have gained a prominent role, in terms of modeling and mining, regarding in particular the so-called 10 nm fiber. Starting from some very basic notions of Biology, we briefly illustrate the recent advances obtained via laboratory experiments on the organization and dynamics of chromatin. Then, we mainly concentrate our attention on the contributions given by Combinatorial and Informational Methodologies, that are at the hearth of Theoretical Computer Science, to the understanding of mechanisms determining the 10 nm fiber. We conclude highlighting several directions of investigation that are perceived as important and where Theoretical Computer Science can provide high impact results

AB - Epigenomics is the study of modifications on the genetic material of a cell that do not depend on changes in the DNA sequence, since those latter involve specific proteins around which DNA wraps. The end result is that Epigenomic changes have a fundamental role in the proper working of each cell in Eukaryotic organisms. A particularly important part of Epigenomics concentrates on the study of chromatin, that is, a fiber composed of a DNA-protein complex and very characterizing of Eukaryotes. Understanding how chromatin is assembled and how it changes is fundamental for Biology. In more than thirty years of research in this area, Mathematics and Theoretical Computer Science have gained a prominent role, in terms of modeling and mining, regarding in particular the so-called 10 nm fiber. Starting from some very basic notions of Biology, we briefly illustrate the recent advances obtained via laboratory experiments on the organization and dynamics of chromatin. Then, we mainly concentrate our attention on the contributions given by Combinatorial and Informational Methodologies, that are at the hearth of Theoretical Computer Science, to the understanding of mechanisms determining the 10 nm fiber. We conclude highlighting several directions of investigation that are perceived as important and where Theoretical Computer Science can provide high impact results

UR - http://hdl.handle.net/10447/305480

UR - http://www.journals.elsevier.com/theoretical-computer-science/

M3 - Article

VL - 792

SP - 117

EP - 130

JO - Theoretical Computer Science

JF - Theoretical Computer Science

SN - 0304-3975

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