DNA Binding Studies and Cytotoxicity of a Dinuclear PtII Diazapyrenium-Based Metallo-supramolecular Rectangular Box

Alessio Terenzi, Giampaolo Barone, Víctor Blanco, Cosimo Ducani, Lenka Zerzankova, Alessio Terenzi, Aron F. Westendorf, Carlos Peinador, Patrick J. Bednarski, José M. Quintela, Michael J. Hannon

Risultato della ricerca: Article

25 Citazioni (Scopus)

Abstract

The interaction with native DNA of a 2,7-diazapyrenium-based ligand 1 and its PtII rectangular metallacycle 2 is explored through circular and linear dichroism and fluorescence spectroscopies. The metal-free ligand 1 binds through intercalation, with a binding constant of approximately 5*105m-1, whereas the metallacycle 2 binds and bends the DNA with a binding constant of 7*106m-1. PCR assays show that metallo-supramolecular box 2 interferes with DNA transactions in vitro whereas the intercalator 1 does not. The metallacycle is active against four human cancer cell lines, with IC50 values ranging between 3.1 and 19.2 mm and shows similar levels of efficacy, but a different spectrum of activity, to cisplatin.
Lingua originaleEnglish
pagine (da-a)10983-10990
Numero di pagine8
RivistaCHEMISTRY-A EUROPEAN JOURNAL
Volume18
Stato di pubblicazionePublished - 2012

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

Cita questo

Terenzi, A., Barone, G., Blanco, V., Ducani, C., Zerzankova, L., Terenzi, A., Westendorf, A. F., Peinador, C., Bednarski, P. J., Quintela, J. M., & Hannon, M. J. (2012). DNA Binding Studies and Cytotoxicity of a Dinuclear PtII Diazapyrenium-Based Metallo-supramolecular Rectangular Box. CHEMISTRY-A EUROPEAN JOURNAL, 18, 10983-10990.