Disability in Moderate Chronic Obstructive Pulmonary Disease: Prevalence, Burden and Assessment - Results from a Real-Life Study

Nicola Scichilone, Claudio Sorino, Eugenio Sabato, Claudio Sorino, Alberto Zolezzi, Sara Balestracci, Giuseppina Cuttitta, Giorgio Walter Canonica, Giuseppe Girbino, Caterina Bucca, Ilaria Baiardini, Maria Pia Foschino Barbaro, Fabiano Di Marco, Carlo Mereu, Angelo Corsico, Giuseppe Di Maria, Fulvio Braido, Pierachille Santus

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)


Background: The role of disability and its association with patient-reported outcomes in the nonsevere forms of chronic obstructive pulmonary disease (COPD) has never been explored. Objectives: The aim of this study was to assess, in a cross-sectional real-life study, the prevalence and degree of disability in moderate COPD patients and to assess its association with health status, illness perception, risk of death and well-being. Methods: Moderate COPD outpatients attending scheduled visits were involved in a quantitative research program using a questionnaire-based data collection method. Results: Out of 694 patients, 17.4% were classified as disabled and 47.6% reported the loss of at least one relevant function of daily living. Disabled patients did not differ from nondisabled patients in terms of working status (p = 0.06), smoking habits (p = 0.134) and ongoing treatment (p = 0.823); however, the former showed a significantly higher disease burden as measured by illness perception, health status and well-being. The stepwise regression analysis showed that the modified Medical Research Council (mMRC) score was the most relevant factor related to COPD disability (F = 38.248; p = 0.001). Patient stratification was possible according to the forced expiratory volume in 1 s (FEV1) value and an mMRC score ≥2, which identified disabled patients, whereas the mMRC values were differently associated with the risk of disability. Conclusion: A significant proportion of individuals with moderate COPD reported a limitation of daily life functions, with dyspnea being the most relevant factor inducing disability. Adding the evaluation of patient-reported outcomes to lung function assessment could facilitate the identification of disabled patients. © 2015 S. Karger AG, Basel
Lingua originaleEnglish
pagine (da-a)100-106
Numero di pagine7
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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