Direct synthesis of C3-mono-functionalized oxindoles from N-unprotected 2-oxindole and their antileishmanial activity

Antonio Cascio, Angela Scala, Giuseppina Barberi, Giovanni Grassi, Massimiliano Cordaro, Francesco Risitano, Antonio Cascio, Anna Piperno

Risultato della ricerca: Article

23 Citazioni (Scopus)

Abstract

A novel approach for the synthesis of unprecedented C3-mono-functionalized indolin-2-ones is reported, starting from 2-oxindole and chalcones. The reactions proceed regioselectively under mild conditions, without di- and tri-alkylated side products. The new compounds have been evaluated in vitro for their antiproliferative effects against the protozoan Leishmania infantum. Interestingly, they appear able to kill L. infantum promastigotes and amastigotes, without significant cytotoxic effects.
Lingua originaleEnglish
pagine (da-a)1063-1069
Numero di pagine7
RivistaBIOORGANIC & MEDICINAL CHEMISTRY
Volume22
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Cascio, A., Scala, A., Barberi, G., Grassi, G., Cordaro, M., Risitano, F., Cascio, A., & Piperno, A. (2014). Direct synthesis of C3-mono-functionalized oxindoles from N-unprotected 2-oxindole and their antileishmanial activity. BIOORGANIC & MEDICINAL CHEMISTRY, 22, 1063-1069.