Background: Studies on pulmonary function tests (PFTs) in Growth Hormone Deﬁciency (GHD) children are lacking. The aims of this study were: (i) to investigate PFTs in GHD pre-pubertal children with respect to Controls, before starting Growth Hormone Therapy (GHT) (T0); (ii) to evaluate changes of PFTs in GHD vs Controls, after 1-year GHT (T1). Forboth aims the mediation analysis (MA) was applied to evaluate the extent to which the relationship between GHD and PFTs could be ascribed to a height-mediated (indirect) or a GH direct eﬀect. Methods: 47 pre-pubertal GHD children (aged 5–14 years) underwent PFTs at T0 and T1. At T0, 47 healthy children matched for age and sex were enrolled as Controls. A MA was performed to assess the relationship between GHD and PFTs and height. Statistical analyses were performed using the statistical software R (https:// cran.r-project.org/mirrors.html). A p-value<0.05 was considered signiﬁcant. Measurements and main results: At T0, PFTs indices were signiﬁcantly lower in GHD than in Controls. From T0 to T1 a signiﬁcant improvement was found in PFTs. The percentages of the mediated eﬀect on FVC, FEV1, FEF25–75% and TLC were<50% at T0, suggesting that the direct eﬀect was prevalent. At T1, the percentages of the mediated eﬀect for spirometry indices were ≥50%, indicating that the indirect (height-mediated) eﬀect was the most relevant. Conclusions: The study shows that pre-pubertal children with GHD have an impairment of lung function not exclusively attributable to the indirect (height-mediated) eﬀect, but also to the direct GH action which is mitigated after 1-year of GHT.
|Numero di pagine||9|
|Stato di pubblicazione||Published - 2018|
All Science Journal Classification (ASJC) codes