Digital control circuitry for the p53 dynamics in cancer cell and apoptosis

Barbaraci, G

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

Experimental work and theoretical models deduce a "digital" response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in feedback. This paper proposes an aerospace architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is not to improve the analysis of the actual mathematical models but to demonstrate the usefulness of such digital circuitry design to detect and predict the cell species dynamics for shedding light on their inner and mutual mechanisms of interaction. Moreover, the cell fate is newly conceived by the modified pulsing mechanism of p53 and other apoptotic species when the digital optimal control is applied to an apoptosis wiring diagram.
Lingua originaleEnglish
pagine (da-a)-
Numero di pagine0
RivistaCentral European Journal of Biology
Volume5
Stato di pubblicazionePublished - 2010

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Theoretical Models
apoptosis
Cells
Apoptosis
DNA damage
DNA Damage
DNA
Electric wiring
Control theory
Neoplasms
Transcription Factors
oncogenes
cells
Mathematical models
Feedback
Oncogenes
antagonists
mathematical models
transcription factors
genomics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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Digital control circuitry for the p53 dynamics in cancer cell and apoptosis. / Barbaraci, G.

In: Central European Journal of Biology, Vol. 5, 2010, pag. -.

Risultato della ricerca: Article

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