Diffusion MRI-based cortical complexity alterations associated with executive function in multiple sclerosis.

Lisa Cipolotti, Geoff J.M. Parker, Nils Muhlert, David H. Miller, Torben Schneider, Varun Sethi, Pankaj Daga, Hamied A. Haroon, Sebastian Ourselin, Claudia A.M. Wheeler-Kingshott, Declan T. Chard, Lisa Cipolotti, Maria A. Ron

Risultato della ricerca: Articlepeer review

15 Citazioni (Scopus)


Purpose: To report a novel magnetic resonance imagingmeasure (diffusion orientational complexity [DOC]) in astudy of people with multiple sclerosis (MS) and healthycontrols and to determine patterns of abnormality, correlationswith conventional diffusion measures, and associationswith cognitive function.Materials and Methods: We performed high angular resolutiondiffusion imaging (HARDI) and measured DOC, meandiffusivity (MD), and fractional anisotropy (FA) in 51 MSpatients and 28 healthy controls. All subjects had a 2-mmisotropic HARDI scan on a 3 T scanner using a 32-channelhead receiver coil. DOC, MD, and FA were measured inthree regions of interest (ROIs) in frontal cortex linked toexecutive function, two ROIs in occipital cortex thoughtunlikely to affect cognition, and in the whole cortex.Results: Frontal cortex DOC was significantly decreasedin MS patients. DOC correlated mostly with FA but not MDin controls and with MD but not FA in people with MS. Inregression models that included all three diffusion-basedmeasures, frontal cortex DOC and frontal cortex FAindependently predicted executive function scores.Conclusion: DOC is a new useful measure of functionallyrelevant cortical pathology in MS, providing informationthat complements conventional diffusion measures.
Lingua originaleUndefined/Unknown
pagine (da-a)54-63
Numero di pagine10
RivistaJournal of Magnetic Resonance
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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