Differential tissue fatty acids profiling between colorectal cancer patients with and without synchronous metastasis

Nicola Veronese, Valeria Tutino, Nicola Veronese, Maria Gabriella Caruso, Valentina De Nunzio, Giampiero De Leonardis, Gisella Marangelli, Maria Notarnicola, Gianluigi Giannelli, Dionigi Lorusso, Vito Guerra

Risultato della ricerca: Articlepeer review

11 Citazioni (Scopus)

Abstract

The early detection of colorectal cancer and determination of its metastatic potential are important factors to set up more efficacious therapeutic strategies. In the present study, we hypothesize that fatty acids analysis in colorectal cancer patients can discriminate between metastatic and non-metastatic patients. Fifty-one consecutive patients with histologically proven colorectal cancer were enrolled in the study and the presence of synchronous metastasis was detected in 25 of these 51 patients. Fatty acid profile analysis in red blood cell membranes was not able to discriminate the metastatic colorectal cancer patients from those without metastasis. However, significant differences in the tumor tissue fatty acid profile were found in metastatic cancer patients when compared to patients without metastasis. Metastatic patients showed significantly lower percentages of Eicosapentaenoic acid (EPA) and higher levels of γ-linolenic acid (GLA), a n-3- and n-6-Polyunsaturated fatty acid (PUFA), respectively. Our findings, suggesting that membrane lipid rearrangement could influence the cellular function and make the cell more prone to metastasis, offer the opportunity to develop nutritional strategies that may be helpful in the prevention and treatment of colorectal cancer. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Lingua originaleEnglish
Numero di pagine8
RivistaInternational Journal of Molecular Sciences
Volume19
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cita questo