BACKGROUND: The presence of oxidative stress in patients with asthma is welldocumented; however, the role of oxidative stress in allergic rhinitis hasreceived less attention, although it is likely to be similar to that observed in patients with asthma. Advanced glycation end products (AGEs) and advancedoxidation protein products (AOPPs) are compounds formed by the transformation of macromolecules, including proteins, which can serve as densitometric markers ofoxidative stress and inflammation in several diseases.OBJECTIVE: The aim of this study was to investigate the role of AGEs and AOPPs asnew markers of oxidative stress and inflammation in patients affected by allergicrhinitis.METHODS: AGE and AOPP levels were determined in the sera of 25 patients withallergic rhinitis and 64 healthy controls. AGEs and AOPPs were detected usingspectrofluorimetry and spectrophotometry, respectively.RESULTS: AGE levels in patients were significantly higher than those in controls (P < .0001). These levels were not affected by the presence of asthma. Nostatistically significant differences were found between AOPP levels in patients or controls (P = .38).CONCLUSIONS: Formation of AGEs and AOPPs may be accelerated in immunological and respiratory disorders such as asthma. Depending on the marker evaluated, thepresence or absence of oxidative stress in allergic rhinitis is controversial. Toour knowledge, this is the first study showing the possible involvement of AGEsin allergic rhinitis. The different behavior observed for these 2 biomarkers isvery likely due to the activation of specific related biochemical pathways (eg, the myeloperoxidase pathway) associated with the condition under study.
|Numero di pagine||6|
|Rivista||JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY|
|Stato di pubblicazione||Published - 2013|
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