Differences in cannabis-related experiences between patients with a first episode of psychosis and controls

Caterina La Cascia, Conrad Iyegbe, Paola Dazzan, Lynskey, Jennifer A. O'Connor, Anthony S. David, Marta Di Forti, Diana Prata, Valeria Mondelli, Anna Kolliakou, Luzi, Robin M. Murray, Simona A. Stilo, Arianna Marconi, Craig Morgan, Bonomo, Bianconi, Gurillo Muñoz, Homayoun

Risultato della ricerca: Article

10 Citazioni (Scopus)

Abstract

Background Many studies have reported that cannabis use increases the risk of a first episode of psychosis (FEP). However, only a few studies have investigated the nature of cannabis-related experiences in FEP patients, and none has examined whether these experiences are similar in FEP and general populations. The aim of this study was to explore differences in self-reported cannabis experiences between FEP and non-psychotic populations. Method A total of 252 subjects, who met International Classification of Diseases (ICD)-10 criteria for FEP, and 217 controls who reported cannabis use were selected from the Genetics and Psychosis (GAP) study. The Medical Research Council Social Schedule and the Cannabis Experience Questionnaire were used to collect sociodemographic data and cannabis use information, respectively. Results Both 'bad' and 'enjoyable' experiences were more commonly reported by FEP subjects than controls. Principal components factor analysis identified four components which explained 62.3% of the variance. Linear regression analysis on the whole sample showed that the type of cannabis used and beliefs about the effect of cannabis on health all contributed to determining the intensity and frequency of experiences. Linear regression analysis on FEP subjects showed that the duration of cannabis use and amount of money spent on cannabis were strongly related to the intensity and frequency of enjoyable experiences in this population. Conclusions These results suggest a higher sensitivity to cannabis effects among people who have suffered their first psychotic episode; this hypersensitivity results in them reporting both more 'bad' and 'enjoyable' experiences. The greater enjoyment experienced may provide an explanation of why FEP patients are more likely to use cannabis and to continue to use it despite experiencing an exacerbation of their psychotic symptoms.
Lingua originaleEnglish
pagine (da-a)995-1003
Numero di pagine9
RivistaPsychological Medicine
Volume46
Stato di pubblicazionePublished - 2016

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Cannabis
Psychotic Disorders
Linear Models
Regression Analysis
Population
International Classification of Diseases
Principal Component Analysis
Statistical Factor Analysis
Biomedical Research
Appointments and Schedules
Hypersensitivity

All Science Journal Classification (ASJC) codes

  • Applied Psychology
  • Psychiatry and Mental health

Cita questo

La Cascia, C., Iyegbe, C., Dazzan, P., Lynskey, O'Connor, J. A., David, A. S., ... Homayoun (2016). Differences in cannabis-related experiences between patients with a first episode of psychosis and controls. Psychological Medicine, 46, 995-1003.

Differences in cannabis-related experiences between patients with a first episode of psychosis and controls. / La Cascia, Caterina; Iyegbe, Conrad; Dazzan, Paola; Lynskey; O'Connor, Jennifer A.; David, Anthony S.; Di Forti, Marta; Prata, Diana; Mondelli, Valeria; Kolliakou, Anna; Luzi; Murray, Robin M.; Stilo, Simona A.; Marconi, Arianna; Morgan, Craig; Bonomo; Bianconi; Gurillo Muñoz; Homayoun.

In: Psychological Medicine, Vol. 46, 2016, pag. 995-1003.

Risultato della ricerca: Article

La Cascia, C, Iyegbe, C, Dazzan, P, Lynskey, O'Connor, JA, David, AS, Di Forti, M, Prata, D, Mondelli, V, Kolliakou, A, Luzi, Murray, RM, Stilo, SA, Marconi, A, Morgan, C, Bonomo, Bianconi, Gurillo Muñoz & Homayoun 2016, 'Differences in cannabis-related experiences between patients with a first episode of psychosis and controls', Psychological Medicine, vol. 46, pagg. 995-1003.
La Cascia, Caterina ; Iyegbe, Conrad ; Dazzan, Paola ; Lynskey ; O'Connor, Jennifer A. ; David, Anthony S. ; Di Forti, Marta ; Prata, Diana ; Mondelli, Valeria ; Kolliakou, Anna ; Luzi ; Murray, Robin M. ; Stilo, Simona A. ; Marconi, Arianna ; Morgan, Craig ; Bonomo ; Bianconi ; Gurillo Muñoz ; Homayoun. / Differences in cannabis-related experiences between patients with a first episode of psychosis and controls. In: Psychological Medicine. 2016 ; Vol. 46. pagg. 995-1003.
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title = "Differences in cannabis-related experiences between patients with a first episode of psychosis and controls",
abstract = "Background Many studies have reported that cannabis use increases the risk of a first episode of psychosis (FEP). However, only a few studies have investigated the nature of cannabis-related experiences in FEP patients, and none has examined whether these experiences are similar in FEP and general populations. The aim of this study was to explore differences in self-reported cannabis experiences between FEP and non-psychotic populations. Method A total of 252 subjects, who met International Classification of Diseases (ICD)-10 criteria for FEP, and 217 controls who reported cannabis use were selected from the Genetics and Psychosis (GAP) study. The Medical Research Council Social Schedule and the Cannabis Experience Questionnaire were used to collect sociodemographic data and cannabis use information, respectively. Results Both 'bad' and 'enjoyable' experiences were more commonly reported by FEP subjects than controls. Principal components factor analysis identified four components which explained 62.3{\%} of the variance. Linear regression analysis on the whole sample showed that the type of cannabis used and beliefs about the effect of cannabis on health all contributed to determining the intensity and frequency of experiences. Linear regression analysis on FEP subjects showed that the duration of cannabis use and amount of money spent on cannabis were strongly related to the intensity and frequency of enjoyable experiences in this population. Conclusions These results suggest a higher sensitivity to cannabis effects among people who have suffered their first psychotic episode; this hypersensitivity results in them reporting both more 'bad' and 'enjoyable' experiences. The greater enjoyment experienced may provide an explanation of why FEP patients are more likely to use cannabis and to continue to use it despite experiencing an exacerbation of their psychotic symptoms.",
author = "{La Cascia}, Caterina and Conrad Iyegbe and Paola Dazzan and Lynskey and O'Connor, {Jennifer A.} and David, {Anthony S.} and {Di Forti}, Marta and Diana Prata and Valeria Mondelli and Anna Kolliakou and Luzi and Murray, {Robin M.} and Stilo, {Simona A.} and Arianna Marconi and Craig Morgan and Bonomo and Bianconi and {Gurillo Mu{\~n}oz} and Homayoun",
year = "2016",
language = "English",
volume = "46",
pages = "995--1003",
journal = "Psychological Medicine",
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T1 - Differences in cannabis-related experiences between patients with a first episode of psychosis and controls

AU - La Cascia, Caterina

AU - Iyegbe, Conrad

AU - Dazzan, Paola

AU - Lynskey, null

AU - O'Connor, Jennifer A.

AU - David, Anthony S.

AU - Di Forti, Marta

AU - Prata, Diana

AU - Mondelli, Valeria

AU - Kolliakou, Anna

AU - Luzi, null

AU - Murray, Robin M.

AU - Stilo, Simona A.

AU - Marconi, Arianna

AU - Morgan, Craig

AU - Bonomo, null

AU - Bianconi, null

AU - Gurillo Muñoz, null

AU - Homayoun, null

PY - 2016

Y1 - 2016

N2 - Background Many studies have reported that cannabis use increases the risk of a first episode of psychosis (FEP). However, only a few studies have investigated the nature of cannabis-related experiences in FEP patients, and none has examined whether these experiences are similar in FEP and general populations. The aim of this study was to explore differences in self-reported cannabis experiences between FEP and non-psychotic populations. Method A total of 252 subjects, who met International Classification of Diseases (ICD)-10 criteria for FEP, and 217 controls who reported cannabis use were selected from the Genetics and Psychosis (GAP) study. The Medical Research Council Social Schedule and the Cannabis Experience Questionnaire were used to collect sociodemographic data and cannabis use information, respectively. Results Both 'bad' and 'enjoyable' experiences were more commonly reported by FEP subjects than controls. Principal components factor analysis identified four components which explained 62.3% of the variance. Linear regression analysis on the whole sample showed that the type of cannabis used and beliefs about the effect of cannabis on health all contributed to determining the intensity and frequency of experiences. Linear regression analysis on FEP subjects showed that the duration of cannabis use and amount of money spent on cannabis were strongly related to the intensity and frequency of enjoyable experiences in this population. Conclusions These results suggest a higher sensitivity to cannabis effects among people who have suffered their first psychotic episode; this hypersensitivity results in them reporting both more 'bad' and 'enjoyable' experiences. The greater enjoyment experienced may provide an explanation of why FEP patients are more likely to use cannabis and to continue to use it despite experiencing an exacerbation of their psychotic symptoms.

AB - Background Many studies have reported that cannabis use increases the risk of a first episode of psychosis (FEP). However, only a few studies have investigated the nature of cannabis-related experiences in FEP patients, and none has examined whether these experiences are similar in FEP and general populations. The aim of this study was to explore differences in self-reported cannabis experiences between FEP and non-psychotic populations. Method A total of 252 subjects, who met International Classification of Diseases (ICD)-10 criteria for FEP, and 217 controls who reported cannabis use were selected from the Genetics and Psychosis (GAP) study. The Medical Research Council Social Schedule and the Cannabis Experience Questionnaire were used to collect sociodemographic data and cannabis use information, respectively. Results Both 'bad' and 'enjoyable' experiences were more commonly reported by FEP subjects than controls. Principal components factor analysis identified four components which explained 62.3% of the variance. Linear regression analysis on the whole sample showed that the type of cannabis used and beliefs about the effect of cannabis on health all contributed to determining the intensity and frequency of experiences. Linear regression analysis on FEP subjects showed that the duration of cannabis use and amount of money spent on cannabis were strongly related to the intensity and frequency of enjoyable experiences in this population. Conclusions These results suggest a higher sensitivity to cannabis effects among people who have suffered their first psychotic episode; this hypersensitivity results in them reporting both more 'bad' and 'enjoyable' experiences. The greater enjoyment experienced may provide an explanation of why FEP patients are more likely to use cannabis and to continue to use it despite experiencing an exacerbation of their psychotic symptoms.

UR - http://hdl.handle.net/10447/244205

UR - http://journals.cambridge.org/action/displayJournal?jid=PSM

M3 - Article

VL - 46

SP - 995

EP - 1003

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

ER -