Difference in Ki67 and Thymidylate Synthase expression in primary tumour compared with metastatic nodes in breast cancer patients.

Sanguedolce R; Rausa L; Cabibi D; Aragona F; Barresi E; Martorana A; And Calascibetta A

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Breast cancer is a heterogeneous disease, so therapeutic predictive biological markers need to be identified. To date an accurate evaluation of predictive markers is mainly done at the primary site; however, the main goal of adjuvant therapy for breast cancer is the control of micrometastases. The aim of this study is to assess as therapeutic and/or prognostic marker, the proliferation status of primary tumors and involved nodes as measured by Ki67 and thymidylate synthase (TS) expression, in 30 breast cancer node positive patients. TS is the main target of 5-fluorouracil (5-FU) activity, and its overexpression is one of the mechanisms of 5-FU drug resistance; however, in some studies its absence is responsible for a worse response to 5-FU. Our results show that malignant cells of involved nodes were in a post mitotic phase of the cell cycle, and show a low proliferation index and TS expression, while the primary tumours and controls, were strongly positive. On these basis we can hypothesize that these cells could be less sensitive to 5-FU. Further studies are necessary to identify other mechanisms responsible for their metastasing capability and/or for their aggressiveness.
Lingua originaleEnglish
pagine (da-a)1193-1196
Numero di pagine4
RivistaNUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS
Volume2006
Stato di pubblicazionePublished - 2006

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Thymidylate Synthase
Fluorouracil
Breast Neoplasms
Neoplasms
Neoplasm Micrometastasis
Drug Resistance
Cell Cycle
Therapeutics
Biomarkers

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Molecular Medicine

Cita questo

Sanguedolce R; Rausa L; Cabibi D; Aragona F; Barresi E; Martorana A; And Calascibetta A (2006). Difference in Ki67 and Thymidylate Synthase expression in primary tumour compared with metastatic nodes in breast cancer patients. NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, 2006, 1193-1196.

Difference in Ki67 and Thymidylate Synthase expression in primary tumour compared with metastatic nodes in breast cancer patients. / Sanguedolce R; Rausa L; Cabibi D; Aragona F; Barresi E; Martorana A; And Calascibetta A.

In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, Vol. 2006, 2006, pag. 1193-1196.

Risultato della ricerca: Article

Sanguedolce R; Rausa L; Cabibi D; Aragona F; Barresi E; Martorana A; And Calascibetta A 2006, 'Difference in Ki67 and Thymidylate Synthase expression in primary tumour compared with metastatic nodes in breast cancer patients.', NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 2006, pagg. 1193-1196.
Sanguedolce R; Rausa L; Cabibi D; Aragona F; Barresi E; Martorana A; And Calascibetta A. / Difference in Ki67 and Thymidylate Synthase expression in primary tumour compared with metastatic nodes in breast cancer patients. In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. 2006 ; Vol. 2006. pagg. 1193-1196.
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title = "Difference in Ki67 and Thymidylate Synthase expression in primary tumour compared with metastatic nodes in breast cancer patients.",
abstract = "Breast cancer is a heterogeneous disease, so therapeutic predictive biological markers need to be identified. To date an accurate evaluation of predictive markers is mainly done at the primary site; however, the main goal of adjuvant therapy for breast cancer is the control of micrometastases. The aim of this study is to assess as therapeutic and/or prognostic marker, the proliferation status of primary tumors and involved nodes as measured by Ki67 and thymidylate synthase (TS) expression, in 30 breast cancer node positive patients. TS is the main target of 5-fluorouracil (5-FU) activity, and its overexpression is one of the mechanisms of 5-FU drug resistance; however, in some studies its absence is responsible for a worse response to 5-FU. Our results show that malignant cells of involved nodes were in a post mitotic phase of the cell cycle, and show a low proliferation index and TS expression, while the primary tumours and controls, were strongly positive. On these basis we can hypothesize that these cells could be less sensitive to 5-FU. Further studies are necessary to identify other mechanisms responsible for their metastasing capability and/or for their aggressiveness.",
author = "{Sanguedolce R; Rausa L; Cabibi D; Aragona F; Barresi E; Martorana A; And Calascibetta A} and Luciano Rausa and Rosario Sanguedolce and Elisabetta Barresi and Daniela Cabibi and Anna Martorana and Anna Calascibetta",
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language = "English",
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pages = "1193--1196",
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T1 - Difference in Ki67 and Thymidylate Synthase expression in primary tumour compared with metastatic nodes in breast cancer patients.

AU - Sanguedolce R; Rausa L; Cabibi D; Aragona F; Barresi E; Martorana A; And Calascibetta A

AU - Rausa, Luciano

AU - Sanguedolce, Rosario

AU - Barresi, Elisabetta

AU - Cabibi, Daniela

AU - Martorana, Anna

AU - Calascibetta, Anna

PY - 2006

Y1 - 2006

N2 - Breast cancer is a heterogeneous disease, so therapeutic predictive biological markers need to be identified. To date an accurate evaluation of predictive markers is mainly done at the primary site; however, the main goal of adjuvant therapy for breast cancer is the control of micrometastases. The aim of this study is to assess as therapeutic and/or prognostic marker, the proliferation status of primary tumors and involved nodes as measured by Ki67 and thymidylate synthase (TS) expression, in 30 breast cancer node positive patients. TS is the main target of 5-fluorouracil (5-FU) activity, and its overexpression is one of the mechanisms of 5-FU drug resistance; however, in some studies its absence is responsible for a worse response to 5-FU. Our results show that malignant cells of involved nodes were in a post mitotic phase of the cell cycle, and show a low proliferation index and TS expression, while the primary tumours and controls, were strongly positive. On these basis we can hypothesize that these cells could be less sensitive to 5-FU. Further studies are necessary to identify other mechanisms responsible for their metastasing capability and/or for their aggressiveness.

AB - Breast cancer is a heterogeneous disease, so therapeutic predictive biological markers need to be identified. To date an accurate evaluation of predictive markers is mainly done at the primary site; however, the main goal of adjuvant therapy for breast cancer is the control of micrometastases. The aim of this study is to assess as therapeutic and/or prognostic marker, the proliferation status of primary tumors and involved nodes as measured by Ki67 and thymidylate synthase (TS) expression, in 30 breast cancer node positive patients. TS is the main target of 5-fluorouracil (5-FU) activity, and its overexpression is one of the mechanisms of 5-FU drug resistance; however, in some studies its absence is responsible for a worse response to 5-FU. Our results show that malignant cells of involved nodes were in a post mitotic phase of the cell cycle, and show a low proliferation index and TS expression, while the primary tumours and controls, were strongly positive. On these basis we can hypothesize that these cells could be less sensitive to 5-FU. Further studies are necessary to identify other mechanisms responsible for their metastasing capability and/or for their aggressiveness.

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VL - 2006

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EP - 1196

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

SN - 0732-8311

ER -