Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways inmany solid tumors. Some gene-expression signatures are already used as predictors of relapse inearly breast cancer patients. The explosion of new information in gene expression profiling couldpotentially lead to the development of tailored treatments in many solid tumors. In addition, manystudies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic,and targeted agents in breast cancer as well as in other tumors.This book has been carried out with the aim of providing readers a useful and comprehensiveresource about the range of applications of microarray technology on oncological diseases.The book is principally addressed to resident and fellow physicians, medical oncologists, molecularbiologists, biotechnologists, and those who study oncological diseases. The chapters have beenwritten by leading international researchers on these topics who have prepared their manuscriptsaccording to current literature and field experience with microarray technology.