Diagnostic and therapeutical role of vitamin D in chronic hepatitis C virus infection.

Calogero Camma', Salvatore Petta, Salvatore Petta, Giuseppe Nunnari, Marilia Rita Pinzone, Anna Nicolosi, Alessandro Cappellani, Antonio Zanghi, Bruno Cacopardo, Calogero Camma

Risultato della ricerca: Articlepeer review

13 Citazioni (Scopus)

Abstract

Although initially identified as a calcium homeostatic hormone, vitamin D is now known to have pleiotropic functions, dealing with both innate and adaptative immunity. Calcitriol mediates its biological effects by binding to the vitamin D receptor (VDR), which is expressed not only by intestine, bone and kidney but also on cell membranes of T lymphocytes, B lymphocytes, dendritic cells and macrophages. Vitamin D plays a role on the degree of liver damage in patients with chronic hepatitis C (CHC): low vitamin D levels have been associated with high hepatic necroinflammatory activity and progression of liver fibrosis. Vitamin D, in CHC patients, could also affect the response to antiviral therapy: in fact, recent studies have shown a relationship between low responsiveness to IFNbased therapy and low vitamin D serum levels. Further studies are required to better assess if vitamin D could work as a reliable noninvasive marker of liver fibrosis and whether vitamin D supplementation could be given to all CHC patients together with standard antiviral treatment, in order to improve the rate of sustained virological response (SVR).
Lingua originaleEnglish
pagine (da-a)1276-1286
Numero di pagine11
RivistaFrontiers in Bioscience
Volume4E
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1300???
  • ???subjectarea.asjc.2400.2400???

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