Diagnostic and prognostic value of H-FABP in acute coronary syndrome: Still evidence to bring

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Abstract

The assessment of chest pain patients presenting to the emergency area (EA) is still a clinical challenge, as the majority of patients are not diagnosed with acute coronary syndrome (ACS). New generation high sensitivity c-Tn (hs-cTn) assays have showed better performances compared to the standard c-Tn. However, hs-Tn still presents some limitations. Hence, novel, early biomarkers are needed in this setting. Among all, heart-type fatty acid binding protein (H-FABP) has been largely investigated. This article reviews the studies evaluating H-FABP performance in diagnosing acute myocardial infarction (AMI) and stratifying chest pain patients by risk. H-FABP optimal performances in ACS have been reported by studies that used low threshold for positivity, or compared the biomarker to cTn at 3–6 h, or by studies with small sample size. Literature review allows stating that H-FABP is clearly not a reliable marker in ACS, as it is unable to diagnose AMI, neither as a stand-alone test nor combined with hs-cTn. Few evidence supports its incremental value in ruling-out AMI and its risk stratification ability for chest pain patients presenting to EA. Thus, available data may not encourage going on investigating.
Lingua originaleEnglish
pagine (da-a)1-4
Numero di pagine4
RivistaClinical Biochemistry
Volume58
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cita questo

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title = "Diagnostic and prognostic value of H-FABP in acute coronary syndrome: Still evidence to bring",
abstract = "The assessment of chest pain patients presenting to the emergency area (EA) is still a clinical challenge, as the majority of patients are not diagnosed with acute coronary syndrome (ACS). New generation high sensitivity c-Tn (hs-cTn) assays have showed better performances compared to the standard c-Tn. However, hs-Tn still presents some limitations. Hence, novel, early biomarkers are needed in this setting. Among all, heart-type fatty acid binding protein (H-FABP) has been largely investigated. This article reviews the studies evaluating H-FABP performance in diagnosing acute myocardial infarction (AMI) and stratifying chest pain patients by risk. H-FABP optimal performances in ACS have been reported by studies that used low threshold for positivity, or compared the biomarker to cTn at 3–6 h, or by studies with small sample size. Literature review allows stating that H-FABP is clearly not a reliable marker in ACS, as it is unable to diagnose AMI, neither as a stand-alone test nor combined with hs-cTn. Few evidence supports its incremental value in ruling-out AMI and its risk stratification ability for chest pain patients presenting to EA. Thus, available data may not encourage going on investigating.",
keywords = "ACS; AMI; Chest pain; H-FABP; Rule-in; Rule-out; Acute Coronary Syndrome; Animals; Biomarkers; Fatty Acid Binding Protein 3; Humans; Predictive Value of Tests; Troponin C; Clinical Biochemistry",
author = "Marcello Ciaccio and Giulia Bivona and Chiara Bellia and {Lo Sasso}, Bruna and Luisa Agnello",
year = "2018",
language = "English",
volume = "58",
pages = "1--4",
journal = "Clinical Biochemistry",
issn = "0009-9120",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Diagnostic and prognostic value of H-FABP in acute coronary syndrome: Still evidence to bring

AU - Ciaccio, Marcello

AU - Bivona, Giulia

AU - Bellia, Chiara

AU - Lo Sasso, Bruna

AU - Agnello, Luisa

PY - 2018

Y1 - 2018

N2 - The assessment of chest pain patients presenting to the emergency area (EA) is still a clinical challenge, as the majority of patients are not diagnosed with acute coronary syndrome (ACS). New generation high sensitivity c-Tn (hs-cTn) assays have showed better performances compared to the standard c-Tn. However, hs-Tn still presents some limitations. Hence, novel, early biomarkers are needed in this setting. Among all, heart-type fatty acid binding protein (H-FABP) has been largely investigated. This article reviews the studies evaluating H-FABP performance in diagnosing acute myocardial infarction (AMI) and stratifying chest pain patients by risk. H-FABP optimal performances in ACS have been reported by studies that used low threshold for positivity, or compared the biomarker to cTn at 3–6 h, or by studies with small sample size. Literature review allows stating that H-FABP is clearly not a reliable marker in ACS, as it is unable to diagnose AMI, neither as a stand-alone test nor combined with hs-cTn. Few evidence supports its incremental value in ruling-out AMI and its risk stratification ability for chest pain patients presenting to EA. Thus, available data may not encourage going on investigating.

AB - The assessment of chest pain patients presenting to the emergency area (EA) is still a clinical challenge, as the majority of patients are not diagnosed with acute coronary syndrome (ACS). New generation high sensitivity c-Tn (hs-cTn) assays have showed better performances compared to the standard c-Tn. However, hs-Tn still presents some limitations. Hence, novel, early biomarkers are needed in this setting. Among all, heart-type fatty acid binding protein (H-FABP) has been largely investigated. This article reviews the studies evaluating H-FABP performance in diagnosing acute myocardial infarction (AMI) and stratifying chest pain patients by risk. H-FABP optimal performances in ACS have been reported by studies that used low threshold for positivity, or compared the biomarker to cTn at 3–6 h, or by studies with small sample size. Literature review allows stating that H-FABP is clearly not a reliable marker in ACS, as it is unable to diagnose AMI, neither as a stand-alone test nor combined with hs-cTn. Few evidence supports its incremental value in ruling-out AMI and its risk stratification ability for chest pain patients presenting to EA. Thus, available data may not encourage going on investigating.

KW - ACS; AMI; Chest pain; H-FABP; Rule-in; Rule-out; Acute Coronary Syndrome; Animals; Biomarkers; Fatty Acid Binding Protein 3; Humans; Predictive Value of Tests; Troponin C; Clinical Biochemistry

UR - http://hdl.handle.net/10447/347217

UR - http://www.elsevier.com/locate/clinbiochem

M3 - Article

VL - 58

SP - 1

EP - 4

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

ER -