Diagnostic accuracy of a new antigen test for sars-cov-2 detection

Francesca Di Gaudio, Andrea Marotta, Marina Di Domenico, Nicola Salzano, Cinzia Bettini, Pietro Internicola, Davide Castrianni, Francesca Di Gaudio, Mariarosaria Boccellino, Alfredo De Rosa, Alessandro De Rosa, Anna Maria Marotta

Risultato della ricerca: Articlepeer review

Abstract

Background and aims: Quick and reliable diagnostic tools play an important role in con-trolling the spread of the SARS-Cov-2 pandemic. The aim of this study was to evaluate the diagnostic accuracy of a new cyto-salivary antigen test aimed at detecting the presence of antigens for SARS-CoV-2, as compared by the gold standard RT-PCR and a lateral flow test. Methods: A total of 433 healthy volunteers were enrolled in the study and the sensitivity and specificity of the new cyto-salivary antigen test were calculated, as compared to the RT-PCR nasopharyngeal swab and to the lateral flow test. Results: A total of 433 samples were collected and tested at the Mediterranean Fair in Palermo from February 2021 until April 2021. The new cyto-salivary antigen had a sensitivity of 100% and a specificity of 94.2%. The sensitivity and the specificity of the lateral flow test were 55% and 100%, respectively. Conclusions: The new cyto-salivary antigen test detected more positive cases than the RT-PCR in a sample of asymptomatic subjects, demonstrating to be a promising tool for a more sensitive diagnosis of COVID-19. Further studies are warranted to better characterize its diagnostic accuracy.
Lingua originaleEnglish
pagine (da-a)6310-
Numero di pagine9
RivistaInternational Journal of Environmental Research and Public Health
Volume18
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2739???
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