Diabetes preceding Parkinson's disease onset. A case-control study

Paolo Aridon, Giovanni Savettieri, Giuseppe Salemi, Marco D'Amelio, Paolo Ragonese, Norma Di Benedetto, Barbara Palmeri, Valeria Terruso, Giorgia Famoso, Marco D'Amelio, Paolo Aridon, Paolo Ragonese, Giuseppe Salemi, Giovanni Savettieri, Graziella Callari, Valeria Terruso

Risultato della ricerca: Article

36 Citazioni (Scopus)

Abstract

Objective: To assess the association between diabetes preceding Parkinson's disease (PD) and PD. Methods: PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption. Results: 318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95% CI, 0.2-0.8). Conclusions: Our findings provide additional support for a potential link between diabetes and PD
Lingua originaleEnglish
pagine (da-a)660-664
Numero di pagine5
RivistaPARKINSONISM & RELATED DISORDERS
Volume15
Stato di pubblicazionePublished - 2009

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Parkinson Disease
Case-Control Studies
Coffee
Alcohol Drinking
Habits
Smoking
Odds Ratio
Body Mass Index
Multivariate Analysis
Logistic Models
Interviews
Education

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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Diabetes preceding Parkinson's disease onset. A case-control study. / Aridon, Paolo; Savettieri, Giovanni; Salemi, Giuseppe; D'Amelio, Marco; Ragonese, Paolo; Di Benedetto, Norma; Palmeri, Barbara; Terruso, Valeria; Famoso, Giorgia; D'Amelio, Marco; Aridon, Paolo; Ragonese, Paolo; Salemi, Giuseppe; Savettieri, Giovanni; Callari, Graziella; Terruso, Valeria.

In: PARKINSONISM & RELATED DISORDERS, Vol. 15, 2009, pag. 660-664.

Risultato della ricerca: Article

Aridon, P, Savettieri, G, Salemi, G, D'Amelio, M, Ragonese, P, Di Benedetto, N, Palmeri, B, Terruso, V, Famoso, G, D'Amelio, M, Aridon, P, Ragonese, P, Salemi, G, Savettieri, G, Callari, G & Terruso, V 2009, 'Diabetes preceding Parkinson's disease onset. A case-control study', PARKINSONISM & RELATED DISORDERS, vol. 15, pagg. 660-664.
Aridon, Paolo ; Savettieri, Giovanni ; Salemi, Giuseppe ; D'Amelio, Marco ; Ragonese, Paolo ; Di Benedetto, Norma ; Palmeri, Barbara ; Terruso, Valeria ; Famoso, Giorgia ; D'Amelio, Marco ; Aridon, Paolo ; Ragonese, Paolo ; Salemi, Giuseppe ; Savettieri, Giovanni ; Callari, Graziella ; Terruso, Valeria. / Diabetes preceding Parkinson's disease onset. A case-control study. In: PARKINSONISM & RELATED DISORDERS. 2009 ; Vol. 15. pagg. 660-664.
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title = "Diabetes preceding Parkinson's disease onset. A case-control study",
abstract = "Objective: To assess the association between diabetes preceding Parkinson's disease (PD) and PD. Methods: PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption. Results: 318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95{\%} CI, 0.2-0.8). Conclusions: Our findings provide additional support for a potential link between diabetes and PD",
author = "Paolo Aridon and Giovanni Savettieri and Giuseppe Salemi and Marco D'Amelio and Paolo Ragonese and {Di Benedetto}, Norma and Barbara Palmeri and Valeria Terruso and Giorgia Famoso and Marco D'Amelio and Paolo Aridon and Paolo Ragonese and Giuseppe Salemi and Giovanni Savettieri and Graziella Callari and Valeria Terruso",
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T1 - Diabetes preceding Parkinson's disease onset. A case-control study

AU - Aridon, Paolo

AU - Savettieri, Giovanni

AU - Salemi, Giuseppe

AU - D'Amelio, Marco

AU - Ragonese, Paolo

AU - Di Benedetto, Norma

AU - Palmeri, Barbara

AU - Terruso, Valeria

AU - Famoso, Giorgia

AU - D'Amelio, Marco

AU - Aridon, Paolo

AU - Ragonese, Paolo

AU - Salemi, Giuseppe

AU - Savettieri, Giovanni

AU - Callari, Graziella

AU - Terruso, Valeria

PY - 2009

Y1 - 2009

N2 - Objective: To assess the association between diabetes preceding Parkinson's disease (PD) and PD. Methods: PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption. Results: 318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95% CI, 0.2-0.8). Conclusions: Our findings provide additional support for a potential link between diabetes and PD

AB - Objective: To assess the association between diabetes preceding Parkinson's disease (PD) and PD. Methods: PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption. Results: 318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95% CI, 0.2-0.8). Conclusions: Our findings provide additional support for a potential link between diabetes and PD

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