Diabetes Mellitus prevalence and control in Sleep Disordered Breathing: the European Sleep Apnea Cohort (ESADA) study.

Maria Rosaria Bonsignore, Athanasia Pataka, Cristina Esquinas, Ulla Anttalainen, Gabriel Roisman, Gianfranco Parati, Heleen Vrints, Jean-Louis Pépin, Walter T. Mcnicholas, Pawel Sliwinski, Brian D. Kent, Giedvar Varoneckas, John-Artur Kvamme, Paschalis Steiropoulos, Piotr Bielicki, Marta Kumor, Ruzena Tkacova, Lynda Hayes, Pierre Escourrou, Richard SchulzAudrey Vitols, Josep M. Montserrat, Thomas Penzel, Giedvar Varoneckas, Gianfranco Parati, Oreste Marrone, Renata Riha, Richard Staats, Martin Pretl, Robert Plywaczewski, Tarja Saaresranta, Johan Verbraecken, Lena Lavie, Juan Fernando Masa, Oreste Marrone, Ingo Fietze, Jan Hedner, Thomas Penzel, Ludger Grote, Ferran Barbe, Carolina Lombardi, Peretz Lavie, Patrick Lévy, Ozen Basoglu, Silke Ryan

Risultato della ricerca: Articlepeer review

121 Citazioni (Scopus)


BACKGROUND: OSA is associated with an increased risk of cardiovascular morbidity. A driver of this is metabolic dysfunction and in particular type 2 diabetes mellitus (T2DM). Priorstudies identifying a link between OSA and T2DM have excluded subjects with undiagnosed T2DM, and there is a lack of population-level data on the interaction between OSA and glycemic control among patients with diabetes. We assessed the relationship between OSA severity and T2DM prevalence and control in a large multinational population.METHODS: We performed a cross-sectional analysis of 6,616 participants in the European Sleep Apnea Cohort (ESADA) study, using multivariate regression analysis to assess T2DM prevalence according to OSA severity, as measured by the oxyhemoglobin desaturation index.Patients with diabetes were identified by previous history and medication prescription, and by screening for undiagnosed diabetes with glycosylated hemoglobin (HbA1c) measurement.The relationship of OSA severity with glycemic control was assessed in diabetic subjects.RESULTS:T2DM prevalence increased with OSA severity, from 6.6% in subjects without OSA to 28.9% in those with severe OSA. Despite adjustment for obesity and other confounding factors, in comparison with subjects free of OSA, patients with mild, moderate, or severedisease had an OR (95% CI) of 1.33 (1.04-1.72), 1.73 (1.33-2.25), and 1.87 (1.45-2.42) (P.001),respectively, for prevalent T2DM. Diabetic subjects with more severe OSA had worse glycemiccontrol, with adjusted mean HbA1c levels 0.72% higher in patients with severe OSA than in those without sleep-disordered breathing (analysis of covariance, P.001).CONCLUSIONS:Increasing OSA severity is associated with increased likelihood of concomitant T2DM and worse diabetic control in patients with T2DM.
Lingua originaleEnglish
pagine (da-a)982-990
Numero di pagine9
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2706???
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