Abstract

Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means Dynamic Light Scattering (DLS) and UV-vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by Thermogravimetric Analysis (TGA) measurements, while the morphology was investigated by Scanning Electron Microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV-vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines.
Lingua originaleEnglish
pagine (da-a)613-623
Numero di pagine11
RivistaDefault journal
Volume475
Stato di pubblicazionePublished - 2014

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Curcumin
Triazoles
Spectrum Analysis
Nanotubes
Cell Line
Drug Carriers
Electron Scanning Microscopy
Solubility
Salts
clay
Water
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cita questo

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title = "Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity.",
abstract = "Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means Dynamic Light Scattering (DLS) and UV-vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by Thermogravimetric Analysis (TGA) measurements, while the morphology was investigated by Scanning Electron Microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV-vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines.",
author = "Stefana Milioto and Marina Massaro and Serena Riela and Colletti, {Carmelo Giuseppe} and Giuseppe Lazzara and Renato Noto and Carla Giordano and Paola Poma and Alessandra Bommarito",
year = "2014",
language = "English",
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TY - JOUR

T1 - Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity.

AU - Milioto, Stefana

AU - Massaro, Marina

AU - Riela, Serena

AU - Colletti, Carmelo Giuseppe

AU - Lazzara, Giuseppe

AU - Noto, Renato

AU - Giordano, Carla

AU - Poma, Paola

AU - Bommarito, Alessandra

PY - 2014

Y1 - 2014

N2 - Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means Dynamic Light Scattering (DLS) and UV-vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by Thermogravimetric Analysis (TGA) measurements, while the morphology was investigated by Scanning Electron Microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV-vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines.

AB - Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means Dynamic Light Scattering (DLS) and UV-vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by Thermogravimetric Analysis (TGA) measurements, while the morphology was investigated by Scanning Electron Microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV-vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines.

UR - http://hdl.handle.net/10447/98116

M3 - Article

VL - 475

SP - 613

EP - 623

JO - Default journal

JF - Default journal

ER -