Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 613-623 |
| Numero di pagine | 11 |
| Rivista | Default journal |
| Volume | 475 |
| Stato di pubblicazione | Published - 2014 |
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All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
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Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity. / Milioto, Stefana; Massaro, Marina; Riela, Serena; Colletti, Carmelo Giuseppe; Lazzara, Giuseppe; Noto, Renato; Giordano, Carla; Poma, Paola; Bommarito, Alessandra.
In: Default journal, Vol. 475, 2014, pag. 613-623.Risultato della ricerca: Article
}
TY - JOUR
T1 - Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity.
AU - Milioto, Stefana
AU - Massaro, Marina
AU - Riela, Serena
AU - Colletti, Carmelo Giuseppe
AU - Lazzara, Giuseppe
AU - Noto, Renato
AU - Giordano, Carla
AU - Poma, Paola
AU - Bommarito, Alessandra
PY - 2014
Y1 - 2014
N2 - Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means Dynamic Light Scattering (DLS) and UV-vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by Thermogravimetric Analysis (TGA) measurements, while the morphology was investigated by Scanning Electron Microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV-vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines.
AB - Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means Dynamic Light Scattering (DLS) and UV-vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by Thermogravimetric Analysis (TGA) measurements, while the morphology was investigated by Scanning Electron Microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV-vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines.
UR - http://hdl.handle.net/10447/98116
M3 - Article
VL - 475
SP - 613
EP - 623
JO - Default journal
JF - Default journal
ER -