Detection of genomic signatures of selection in the North African Brune de l’Atlas cattle

Risultato della ricerca: Other

Abstract

The identification of signatures of selection in indigenous livestock genome is able toelucidate the adaptive mechanisms allowing them to cope with environmentalpressures. In the present study, we used genotyping data from 106 Brune de l’Atlascattle individuals and tests based on the extent of haplotype homozygosity (EHH) tolook for footprints of natural selection. We identified 17 genomic regions displayingstrong signal of selection (p-value <10-6) overlapping with previously described QTLregions affecting many traits such as meat and milk composition, tuberculosissusceptibility, tick and mastitis resistance. Some of these highly significant candidateregions overlap with four previously described copy number variation regions(CNVRs) suggesting a possible involvement of these CNVRs in local adaptation ofthe Brune de l'Atlas population. Twelve candidate genes located within 25 kb of themost significant SNPs of the highly significant regions, were identified. Theirphysiological functions were mainly related to protein methylation, regulation oftranscription, immune system homeostasis, ATP transport and regulation of GTPaseactivity. Our results represent the first study providing evidence for selectionfootprints in the North African cattle and could help to emphasize the importance topreserve local breeds to cope with challenges related to climate change
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2018

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