TY - JOUR
T1 - Detectable interleukin-9 plasma levels are associated with impaired cardiopulmonary functional capacity and all-cause mortality in patients with chronic heart failure
AU - Misiano, Gabriella
AU - Arcopinto, Michele
AU - Vigorito, Carlo
AU - Bobbio, Emanuele
AU - Salzano, Andrea
AU - Isidori, Andrea M.
AU - Bossone, Eduardo
AU - Marra, Alberto M.
AU - Perrone-Filardi, Pasquale
AU - Cittadini, Antonio
AU - Ferrara, Francesco
AU - Napoli, Raffaele
AU - Giallauria, Francesco
AU - Vriz, Olga
AU - Triggiani, Vincenzo
AU - Vigorito, Carlo
AU - Napoli, Raffaele
AU - Saccà, Francesco
AU - Milano, Salvatore
PY - 2016
Y1 - 2016
N2 - Inflammatory activation plays a pivotal role in chronic heart failure (CHF) through the increased expression of pro-inflammatory cytokines [1]. Decreased plasma levels of Interleukin (IL-) 5, IL-7 and Interferon-γ (IFN-γ) and increased levels of IL-9 have been already described in CHF [2], and a negative correlation was also reported between IL-9 and left ventricular ejection fraction (LVEF) [2]. Yet, there are only limited data exploring the association between cytokines and functional capacity in CHF and their prognostic role [3]; therefore, primary end-point of the current study was to evaluate all-cause mortality according to changes in cytokines plasma levels in CHF patients.
AB - Inflammatory activation plays a pivotal role in chronic heart failure (CHF) through the increased expression of pro-inflammatory cytokines [1]. Decreased plasma levels of Interleukin (IL-) 5, IL-7 and Interferon-γ (IFN-γ) and increased levels of IL-9 have been already described in CHF [2], and a negative correlation was also reported between IL-9 and left ventricular ejection fraction (LVEF) [2]. Yet, there are only limited data exploring the association between cytokines and functional capacity in CHF and their prognostic role [3]; therefore, primary end-point of the current study was to evaluate all-cause mortality according to changes in cytokines plasma levels in CHF patients.
UR - http://hdl.handle.net/10447/250599
M3 - Article
VL - 209
SP - 114
EP - 117
JO - INTERNATIONAL JOURNAL OF CARDIOLOGY
JF - INTERNATIONAL JOURNAL OF CARDIOLOGY
SN - 0167-5273
ER -