TY - JOUR
T1 - Depression is associated with poor control of symptoms in asthma and rhinitis: A population-based study
AU - Battaglia, Salvatore
AU - Marcon, Alessandro
AU - Grosso, Amelia
AU - Pesce, Giancarlo
AU - Marchetti, Pierpaolo
AU - Albicini, Federica
AU - Piloni, Davide
AU - Antonicelli, Leonardo
AU - Gini, Erica
AU - Verlato, Giuseppe
AU - Ferrari, Marcello
AU - Piccioni, Pavilio
AU - Corsico, Angelo Guido
AU - Fois, Alessandro
AU - Verlato, Giuseppe
AU - Ferrari, Marcello
PY - 2019
Y1 - 2019
N2 - Background: Although many studies have highlighted the link between asthma/rhinitis and depression, it is still unclear which characteristics of these diseases are associated with the risk of depression. We aimed to explore the relationship between depression and asthma or rhinitis in a representative sample of the Italian general population. Methods: The data were collected in GEIRD, an Italian multicenter, population-based, multicase-control study. 2227 participants (age 21–86 years, female 50%) underwent standardized interviews, skin prick and lung function tests, and were divided into cases of current asthma (n = 528), rhinitis without asthma (n = 972), and controls (n = 727). Two specific questions from the Patient Health Questionnaire (PHQ-2) were asked to identify symptoms of depressed mood and anhedonia, which were used as a proxy of major depression disorder. Results: The prevalence of depression was 16.7%, 11.9%, and 5.1% in subjects with asthma, rhinitis and controls, respectively. Both in asthma and rhinitis, subjects with depression had worse respiratory-health related quality of life and more frequent disease-related symptoms than their non-depressed counterparts. In asthma, depression was associated with poorer disease control. In rhinitis, depression was significantly associated with a disease-related limitations in daily activities and greater risk of symptom exacerbations and prescriptions of medicines for breathing. Cases of rhinitis with depression were less likely to be atopic. Conclusions: Our results suggest that rhinitis exacerbations, particularly in non-atopic subjects, and low asthma control are strongly related to the presence of depressed mood in adults from the general population.
AB - Background: Although many studies have highlighted the link between asthma/rhinitis and depression, it is still unclear which characteristics of these diseases are associated with the risk of depression. We aimed to explore the relationship between depression and asthma or rhinitis in a representative sample of the Italian general population. Methods: The data were collected in GEIRD, an Italian multicenter, population-based, multicase-control study. 2227 participants (age 21–86 years, female 50%) underwent standardized interviews, skin prick and lung function tests, and were divided into cases of current asthma (n = 528), rhinitis without asthma (n = 972), and controls (n = 727). Two specific questions from the Patient Health Questionnaire (PHQ-2) were asked to identify symptoms of depressed mood and anhedonia, which were used as a proxy of major depression disorder. Results: The prevalence of depression was 16.7%, 11.9%, and 5.1% in subjects with asthma, rhinitis and controls, respectively. Both in asthma and rhinitis, subjects with depression had worse respiratory-health related quality of life and more frequent disease-related symptoms than their non-depressed counterparts. In asthma, depression was associated with poorer disease control. In rhinitis, depression was significantly associated with a disease-related limitations in daily activities and greater risk of symptom exacerbations and prescriptions of medicines for breathing. Cases of rhinitis with depression were less likely to be atopic. Conclusions: Our results suggest that rhinitis exacerbations, particularly in non-atopic subjects, and low asthma control are strongly related to the presence of depressed mood in adults from the general population.
KW - Asthma control
KW - Atopy
KW - Depression
KW - General population
KW - Rhinitis control
KW - Asthma control
KW - Atopy
KW - Depression
KW - General population
KW - Rhinitis control
UR - http://hdl.handle.net/10447/362985
UR - http://www.harcourt-international.com/journals/rmed/
M3 - Article
VL - 155
SP - 6
EP - 12
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
ER -