TY - JOUR
T1 - Densely PEGylated polybenzofulvene brushes for potential applications in drug encapsulation
AU - Scialabba, Cinzia
AU - Licciardi, Mariano
AU - Dattilo, Sandro
AU - Boccia, Antonella Caterina
AU - Paolino, Marco
AU - Grisci, Giorgio
AU - Piovani, Daniele
AU - Castriconi, Federica
AU - Gentile, Mariangela
AU - Reale, Annalisa
AU - Piovani, Daniele
AU - Piovani, Daniele
AU - Paccagnini, Eugenio
AU - Bonechi, Claudia
AU - Samperi, Filippo
AU - Canetti, Maurizio
AU - Mendichi, Raniero
AU - Donati, Alessandro
AU - Cappelli, Andrea
AU - Giuliani, Germano
AU - Giorgi, Gianluca
PY - 2018
Y1 - 2018
N2 - The technique of grafting side chains onto a linear polymeric backbone is commonly used to confer to the new polymeric material with desired properties, such as tunable solubility, ionic charge, biocompatibility, or specific interactions with biological systems. In this paper, two new polybenzofulvene backbones were assembled by spontaneous polymerization of the appropriate benzofulvene monomers (4,6-PO-BF3k and 4’,6-PO-BF3k) bearing two clickable propargyloxy groups in different positions of the 3-phenylindene scaffold. Poly-4,6-PO-BF3k and poly-4’,6-PO-BF3k were grafted with monomethyl oligo(ethylene glycol) (MOEG) to prepare two new polybenzofulvene brushes (i.e., poly-4,6-MOEG-9-TM-BF3k and poly-4’,6-MOEG-9-TM-BF3k) by means of a “grafting onto” approach, that were characterized from the point of view of their macromolecular features, aggregation liability, and in a preliminary evaluation of biocompatibility. The obtained results make these PEGylated polybenzofulvene brushes (PPBFB) derivatives potentially useful as nanocarriers for nanoencapsulation and delivery of drug molecules.
AB - The technique of grafting side chains onto a linear polymeric backbone is commonly used to confer to the new polymeric material with desired properties, such as tunable solubility, ionic charge, biocompatibility, or specific interactions with biological systems. In this paper, two new polybenzofulvene backbones were assembled by spontaneous polymerization of the appropriate benzofulvene monomers (4,6-PO-BF3k and 4’,6-PO-BF3k) bearing two clickable propargyloxy groups in different positions of the 3-phenylindene scaffold. Poly-4,6-PO-BF3k and poly-4’,6-PO-BF3k were grafted with monomethyl oligo(ethylene glycol) (MOEG) to prepare two new polybenzofulvene brushes (i.e., poly-4,6-MOEG-9-TM-BF3k and poly-4’,6-MOEG-9-TM-BF3k) by means of a “grafting onto” approach, that were characterized from the point of view of their macromolecular features, aggregation liability, and in a preliminary evaluation of biocompatibility. The obtained results make these PEGylated polybenzofulvene brushes (PPBFB) derivatives potentially useful as nanocarriers for nanoencapsulation and delivery of drug molecules.
KW - Affinity polymerization
KW - Drug delivery systems
KW - Grafting onto
KW - Nanocarrier
KW - PEGylation
KW - Polybenzofulvene
KW - Spontaneous polymerization
KW - Affinity polymerization
KW - Drug delivery systems
KW - Grafting onto
KW - Nanocarrier
KW - PEGylation
KW - Polybenzofulvene
KW - Spontaneous polymerization
UR - http://hdl.handle.net/10447/319794
M3 - Article
VL - 10
SP - 234-
JO - Pharmaceutics
JF - Pharmaceutics
SN - 1999-4923
ER -