Densely PEGylated polybenzofulvene brushes for potential applications in drug encapsulation

Mariano Licciardi, Cinzia Scialabba, Sandro Dattilo, Antonella Caterina Boccia, Marco Paolino, Giorgio Grisci, Daniele Piovani, Federica Castriconi, Mariangela Gentile, Annalisa Reale, Eugenio Paccagnini, Claudia Bonechi, Filippo Samperi, Maurizio Canetti, Raniero Mendichi, Alessandro Donati, Andrea Cappelli, Germano Giuliani, Gianluca Giorgi

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

The technique of grafting side chains onto a linear polymeric backbone is commonly used to confer to the new polymeric material with desired properties, such as tunable solubility, ionic charge, biocompatibility, or specific interactions with biological systems. In this paper, two new polybenzofulvene backbones were assembled by spontaneous polymerization of the appropriate benzofulvene monomers (4,6-PO-BF3k and 4’,6-PO-BF3k) bearing two clickable propargyloxy groups in different positions of the 3-phenylindene scaffold. Poly-4,6-PO-BF3k and poly-4’,6-PO-BF3k were grafted with monomethyl oligo(ethylene glycol) (MOEG) to prepare two new polybenzofulvene brushes (i.e., poly-4,6-MOEG-9-TM-BF3k and poly-4’,6-MOEG-9-TM-BF3k) by means of a “grafting onto” approach, that were characterized from the point of view of their macromolecular features, aggregation liability, and in a preliminary evaluation of biocompatibility. The obtained results make these PEGylated polybenzofulvene brushes (PPBFB) derivatives potentially useful as nanocarriers for nanoencapsulation and delivery of drug molecules.
Lingua originaleEnglish
pagine (da-a)234-
Numero di pagine28
RivistaPharmaceutics
Volume10
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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    Licciardi, M., Scialabba, C., Dattilo, S., Boccia, A. C., Paolino, M., Grisci, G., Piovani, D., Castriconi, F., Gentile, M., Reale, A., Paccagnini, E., Bonechi, C., Samperi, F., Canetti, M., Mendichi, R., Donati, A., Cappelli, A., Giuliani, G., & Giorgi, G. (2018). Densely PEGylated polybenzofulvene brushes for potential applications in drug encapsulation. Pharmaceutics, 10, 234-.