Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells

Nicolò Mauro, Valerio Magnaghi, Elisabetta Ranucci, Paolo Ferruti, Michele Laus, Amedea Manfredi, Patrizia Procacci, Diego Antonioli, Nicolò Mauro, Cristina Mantovani

Risultato della ricerca: Article

16 Citazioni (Scopus)

Abstract

This paper reports on the synthesis and physico-chemical, mechanical, and biological characterization of two sets of poly(amidoamine) (PAA) hydrogels with potential as scaffolds for in vivo peripheral nerve regeneration. They are obtained by polyaddition of piperazine with N,N′-methylenebis(acrylamide) or 1,4-bis(acryloyl)piperazine with 1,2-diaminoethane as cross-linking agent and exhibit a combination of relevant properties, such as mechanical strength, biocompatibility, biodegradability, ability to induce adhesion and proliferation of Schwann cells (SCs) preserving their viability. Moreover, the most promising hydrogels, that is those deriving from 1,4-bis(acryloyl)piperazine, allow the in vitro growth of the sensitive neurons of the dorsal root ganglia, thus getting around a critical point in the design of conduits for nerve regeneration. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Lingua originaleEnglish
pagine (da-a)332-347
Numero di pagine16
RivistaMacromolecular Bioscience
Volume13
Stato di pubblicazionePublished - 2013

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Hydrogels
Peripheral Nervous System
Neurology
Scaffolds
Nerve Regeneration
ethylenediamine
Biodegradability
Biocompatibility
Neurons
Strength of materials
Adhesion
Acrylamide
Schwann Cells
Cells
Spinal Ganglia
Peripheral Nerves
Growth
piperazine
Poly(amidoamine)
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Materials Chemistry
  • Polymers and Plastics
  • Biomaterials
  • Bioengineering

Cita questo

Mauro, N., Magnaghi, V., Ranucci, E., Ferruti, P., Laus, M., Manfredi, A., ... Mantovani, C. (2013). Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells. Macromolecular Bioscience, 13, 332-347.

Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells. / Mauro, Nicolò; Magnaghi, Valerio; Ranucci, Elisabetta; Ferruti, Paolo; Laus, Michele; Manfredi, Amedea; Procacci, Patrizia; Antonioli, Diego; Mauro, Nicolò; Mantovani, Cristina.

In: Macromolecular Bioscience, Vol. 13, 2013, pag. 332-347.

Risultato della ricerca: Article

Mauro, N, Magnaghi, V, Ranucci, E, Ferruti, P, Laus, M, Manfredi, A, Procacci, P, Antonioli, D, Mauro, N & Mantovani, C 2013, 'Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells', Macromolecular Bioscience, vol. 13, pagg. 332-347.
Mauro, Nicolò ; Magnaghi, Valerio ; Ranucci, Elisabetta ; Ferruti, Paolo ; Laus, Michele ; Manfredi, Amedea ; Procacci, Patrizia ; Antonioli, Diego ; Mauro, Nicolò ; Mantovani, Cristina. / Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells. In: Macromolecular Bioscience. 2013 ; Vol. 13. pagg. 332-347.
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AU - Ranucci, Elisabetta

AU - Ferruti, Paolo

AU - Laus, Michele

AU - Manfredi, Amedea

AU - Procacci, Patrizia

AU - Antonioli, Diego

AU - Mauro, Nicolò

AU - Mantovani, Cristina

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AB - This paper reports on the synthesis and physico-chemical, mechanical, and biological characterization of two sets of poly(amidoamine) (PAA) hydrogels with potential as scaffolds for in vivo peripheral nerve regeneration. They are obtained by polyaddition of piperazine with N,N′-methylenebis(acrylamide) or 1,4-bis(acryloyl)piperazine with 1,2-diaminoethane as cross-linking agent and exhibit a combination of relevant properties, such as mechanical strength, biocompatibility, biodegradability, ability to induce adhesion and proliferation of Schwann cells (SCs) preserving their viability. Moreover, the most promising hydrogels, that is those deriving from 1,4-bis(acryloyl)piperazine, allow the in vitro growth of the sensitive neurons of the dorsal root ganglia, thus getting around a critical point in the design of conduits for nerve regeneration. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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