Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells

Nicolò Mauro, Diego Antonioli, Nicolò Mauro, Cristina Mantovani, Valerio Magnaghi, Elisabetta Ranucci, Paolo Ferruti, Michele Laus, Amedea Manfredi, Patrizia Procacci

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17 Citazioni (Scopus)

Abstract

This paper reports on the synthesis and physico-chemical, mechanical, and biological characterization of two sets of poly(amidoamine) (PAA) hydrogels with potential as scaffolds for in vivo peripheral nerve regeneration. They are obtained by polyaddition of piperazine with N,N′-methylenebis(acrylamide) or 1,4-bis(acryloyl)piperazine with 1,2-diaminoethane as cross-linking agent and exhibit a combination of relevant properties, such as mechanical strength, biocompatibility, biodegradability, ability to induce adhesion and proliferation of Schwann cells (SCs) preserving their viability. Moreover, the most promising hydrogels, that is those deriving from 1,4-bis(acryloyl)piperazine, allow the in vitro growth of the sensitive neurons of the dorsal root ganglia, thus getting around a critical point in the design of conduits for nerve regeneration. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Lingua originaleEnglish
pagine (da-a)332-347
Numero di pagine16
RivistaMacromolecular Bioscience
Volume13
Stato di pubblicazionePublished - 2013

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cita questo

Mauro, N., Antonioli, D., Mauro, N., Mantovani, C., Magnaghi, V., Ranucci, E., Ferruti, P., Laus, M., Manfredi, A., & Procacci, P. (2013). Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells. Macromolecular Bioscience, 13, 332-347.