Definition of the upper reference limit of glycated albumin in blood donors from Italy

Luisa Agnello, Marcello Ciaccio, Bruna Lo Sasso, Chiara Bellia, Giulia Bivona, Chiara Cosma, Bruna Lo Sasso, Mario Plebani, Martina Zaninotto

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Abstract

Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany). The upper reference limit (URL) was calculated using the non-parametric percentile method. A modest, although significant, increase of GA was observed in relation to age (p<0.001), especially in males, where the differences were more pronounced (p<0.001 in males, p=0.003 in females). Slight differences were documented based on sex (12% [11.3-12.8] in males; 12.2% [11.4-13.1] in females; p=0.01). After excluding individuals with fasting plasma glucose â¥7 mmol/L, the calculated GA URL was 14.5% (95% CI: 14.3-14.7). Subjects with GA>14.5% presented a mean age of 48.4±12.2 years, 66.7% were males and the mean glucose was 6.88±2.5 mmol/L. GA in Caucasians shows a similar increasing trend at older ages documented in other ethnicities. The definition of the URL in this population could be useful for both clinical studies, which will clarify the role of GA for diagnosing and monitoring diabetes, and will encourage the introduction of GA in clinical practice.
Lingua originaleEnglish
pagine (da-a)120-125
Numero di pagine6
RivistaClinical Chemistry and Laboratory Medicine
Volume56
Stato di pubblicazionePublished - 2017

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Blood Donors
Italy
Blood
glycosylated serum albumin
Medical problems
Germany
Homeostasis
Demography
Glucose
Monitoring
Population

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cita questo

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title = "Definition of the upper reference limit of glycated albumin in blood donors from Italy",
abstract = "Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany). The upper reference limit (URL) was calculated using the non-parametric percentile method. A modest, although significant, increase of GA was observed in relation to age (p<0.001), especially in males, where the differences were more pronounced (p<0.001 in males, p=0.003 in females). Slight differences were documented based on sex (12{\%} [11.3-12.8] in males; 12.2{\%} [11.4-13.1] in females; p=0.01). After excluding individuals with fasting plasma glucose {\^a}¥7 mmol/L, the calculated GA URL was 14.5{\%} (95{\%} CI: 14.3-14.7). Subjects with GA>14.5{\%} presented a mean age of 48.4{\^A}±12.2 years, 66.7{\%} were males and the mean glucose was 6.88{\^A}±2.5 mmol/L. GA in Caucasians shows a similar increasing trend at older ages documented in other ethnicities. The definition of the URL in this population could be useful for both clinical studies, which will clarify the role of GA for diagnosing and monitoring diabetes, and will encourage the introduction of GA in clinical practice.",
keywords = "Adolescent, Adult, Aged, Biochemistry (medical), Blood Donors, Clinical Biochemistry, Enzyme Assays, Female, Humans, Italy, Male, Middle Aged, Reference Values, Serum Albumin, Young Adult, blood donors, diabetes, glycated albumin, reference limit",
author = "Luisa Agnello and Marcello Ciaccio and {Lo Sasso}, Bruna and Chiara Bellia and Giulia Bivona and Chiara Cosma and Sasso, {Bruna Lo} and Mario Plebani and Martina Zaninotto",
year = "2017",
language = "English",
volume = "56",
pages = "120--125",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH & Co. KG",

}

TY - JOUR

T1 - Definition of the upper reference limit of glycated albumin in blood donors from Italy

AU - Agnello, Luisa

AU - Ciaccio, Marcello

AU - Lo Sasso, Bruna

AU - Bellia, Chiara

AU - Bivona, Giulia

AU - Cosma, Chiara

AU - Sasso, Bruna Lo

AU - Plebani, Mario

AU - Zaninotto, Martina

PY - 2017

Y1 - 2017

N2 - Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany). The upper reference limit (URL) was calculated using the non-parametric percentile method. A modest, although significant, increase of GA was observed in relation to age (p<0.001), especially in males, where the differences were more pronounced (p<0.001 in males, p=0.003 in females). Slight differences were documented based on sex (12% [11.3-12.8] in males; 12.2% [11.4-13.1] in females; p=0.01). After excluding individuals with fasting plasma glucose â¥7 mmol/L, the calculated GA URL was 14.5% (95% CI: 14.3-14.7). Subjects with GA>14.5% presented a mean age of 48.4±12.2 years, 66.7% were males and the mean glucose was 6.88±2.5 mmol/L. GA in Caucasians shows a similar increasing trend at older ages documented in other ethnicities. The definition of the URL in this population could be useful for both clinical studies, which will clarify the role of GA for diagnosing and monitoring diabetes, and will encourage the introduction of GA in clinical practice.

AB - Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany). The upper reference limit (URL) was calculated using the non-parametric percentile method. A modest, although significant, increase of GA was observed in relation to age (p<0.001), especially in males, where the differences were more pronounced (p<0.001 in males, p=0.003 in females). Slight differences were documented based on sex (12% [11.3-12.8] in males; 12.2% [11.4-13.1] in females; p=0.01). After excluding individuals with fasting plasma glucose â¥7 mmol/L, the calculated GA URL was 14.5% (95% CI: 14.3-14.7). Subjects with GA>14.5% presented a mean age of 48.4±12.2 years, 66.7% were males and the mean glucose was 6.88±2.5 mmol/L. GA in Caucasians shows a similar increasing trend at older ages documented in other ethnicities. The definition of the URL in this population could be useful for both clinical studies, which will clarify the role of GA for diagnosing and monitoring diabetes, and will encourage the introduction of GA in clinical practice.

KW - Adolescent

KW - Adult

KW - Aged

KW - Biochemistry (medical)

KW - Blood Donors

KW - Clinical Biochemistry

KW - Enzyme Assays

KW - Female

KW - Humans

KW - Italy

KW - Male

KW - Middle Aged

KW - Reference Values

KW - Serum Albumin

KW - Young Adult

KW - blood donors

KW - diabetes

KW - glycated albumin

KW - reference limit

UR - http://hdl.handle.net/10447/251828

UR - http://www.reference-global.com/toc/cclm/current

M3 - Article

VL - 56

SP - 120

EP - 125

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

ER -