Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 11-17 |
| Numero di pagine | 7 |
| Rivista | Clinical Hemorheology and Microcirculation |
| Volume | 33 |
| Stato di pubblicazione | Published - 2005 |
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All Science Journal Classification (ASJC) codes
- Hematology
- Physiology
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Deep venous thrombosis: behaviour of the polymorphonuclear leukocyte integrin pattern at baseline and after in vitro activation. / Caimi, Gregorio; Ferrara, Filippo; Lo Presti, Rosalia; Canino, Baldassare; Calandrino, Vincenzo; Tozzi Ciancarelli, Maria Giuliana; Caimi, Gregorio.
In: Clinical Hemorheology and Microcirculation, Vol. 33, 2005, pag. 11-17.Risultato della ricerca: Article
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TY - JOUR
T1 - Deep venous thrombosis: behaviour of the polymorphonuclear leukocyte integrin pattern at baseline and after in vitro activation
AU - Caimi, Gregorio
AU - Ferrara, Filippo
AU - Lo Presti, Rosalia
AU - Canino, Baldassare
AU - Calandrino, Vincenzo
AU - Tozzi Ciancarelli, Maria Giuliana
AU - Caimi, Gregorio
PY - 2005
Y1 - 2005
N2 - In a group of 18 subjects with acute deep venous thrombosis (DVT), evidenced by clinical examination and echo-color-Doppler, we examined the phenotypical expression of the polymorphonuclear leukocyte (PMN) beta2-integrins (CD11a, CD11b, CD11c, CD18), obtained by using a flow cytofluorimeter. The evaluation was performed before and after in vitro activation (prolonged for 5 and 15 minutes) with 4-phorbol 12-myristate 13-acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP). In DVT subjects, at baseline, the phenotypical expression of CD11b was decreased and that of CD11c was increased when compared with normal controls; no difference was found in CD11a and CD18 expression. In normal subjects PMN activation with both activators led to a constant increase of all PMN adhesion molecules; in DVT subjects CD11b, CD11c and CD18 increased, while CD11a expression did not show any change. These data indicate the presence of a functional alteration in circulating PMN cells from patients with DVT.
AB - In a group of 18 subjects with acute deep venous thrombosis (DVT), evidenced by clinical examination and echo-color-Doppler, we examined the phenotypical expression of the polymorphonuclear leukocyte (PMN) beta2-integrins (CD11a, CD11b, CD11c, CD18), obtained by using a flow cytofluorimeter. The evaluation was performed before and after in vitro activation (prolonged for 5 and 15 minutes) with 4-phorbol 12-myristate 13-acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP). In DVT subjects, at baseline, the phenotypical expression of CD11b was decreased and that of CD11c was increased when compared with normal controls; no difference was found in CD11a and CD18 expression. In normal subjects PMN activation with both activators led to a constant increase of all PMN adhesion molecules; in DVT subjects CD11b, CD11c and CD18 increased, while CD11a expression did not show any change. These data indicate the presence of a functional alteration in circulating PMN cells from patients with DVT.
UR - http://hdl.handle.net/10447/3273
UR - https://web.b.ebscohost.com/ehost/detail/detail?vid=0&sid=2c6573bb-3e4b-4b1a-bf29-f82b63400d6f%40sessionmgr103&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#AN=16037628&db=mdc
M3 - Article
VL - 33
SP - 11
EP - 17
JO - Clinical Hemorheology and Microcirculation
JF - Clinical Hemorheology and Microcirculation
SN - 1386-0291
ER -