Deep learning architectures for prediction of nucleosome positioning from sequences data

Giosue' Lo Bosco, Mattia Di Gangi, Giosuè Lo Bosco, Riccardo Rizzo, Riccardo Rizzo

Risultato della ricerca: Articlepeer review

18 Citazioni (Scopus)


Background: Nucleosomes are DNA-histone complex, each wrapping about 150 pairs of double-stranded DNA. Their function is fundamental for one of the primary functions of Chromatin i.e. packing the DNA into the nucleus of the Eukaryote cells. Several biological studies have shown that the nucleosome positioning influences the regulation of cell type-specific gene activities. Moreover, computational studies have shown evidence of sequence specificity concerning the DNA fragment wrapped into nucleosomes, clearly underlined by the organization of particular DNA substrings. As the main consequence, the identification of nucleosomes on a genomic scale has been successfully performed by computational methods using a sequence features representation.Results: In this work, we propose a deep learning model for nucleosome identification. Our model stacks convolutional layers and Long Short-term Memories to automatically extract features from short- and long-range dependencies in a sequence. Using this model we are able to avoid the feature extraction and selection steps while improving the classification performances.Conclusions: Results computed on eleven data sets of five different organisms, from Yeast to Human, show the superiority of the proposed method with respect to the state of the art recently presented in the literature.
Lingua originaleEnglish
pagine (da-a)127-135
Numero di pagine9
RivistaBMC Bioinformatics
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1303???
  • ???subjectarea.asjc.1300.1312???
  • ???subjectarea.asjc.1700.1706???
  • ???subjectarea.asjc.2600.2604???


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