Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe

Salvatrice Mancuso, Loveleen Bansi, Iuri Fanti, Mattia C.F. Prosperi, Anne-Mieke Vandamme, Kristel Van Laethem, David Dunn, Rolf Kaiser, David A.M.C. Van De Vijver, David Asboe, Ricardo Camacho, Simona Di Giambenedetto, Valeria Ghisetti, Carlo Torti, Maurizio Zazzi, Anders Sönnerborg, Andrea De Luca, Francisco M. Codoñer, Ricardo Camacho

Risultato della ricerca: Articlepeer review

50 Citazioni (Scopus)

Abstract

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis. © 2013 The Author.
Lingua originaleEnglish
pagine (da-a)1216-1220
Numero di pagine5
RivistaTHE JOURNAL OF INFECTIOUS DISEASES
Volume207
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2725???

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