Data mining from a 27-years rotavirus surveillance in Palermo, Italy

Claudia Colomba, Antonio Cascio, Simona De Grazia, Giovanni Giammanco, Francesca Di Bernardo, Diane M. Terranova, Vito Martella, Antonina Collura, Antonio Cascio, Floriana Bonura

Risultato della ricerca: Articlepeer review

18 Citazioni (Scopus)


Uninterrupted surveillance conducted in Palermo, Sicily, for 27 years (1985–2012) detected rotavirus infection in 32.7% of 6522 children <5 years of age, hospitalised at the “G. Di Cristina” Children’s Hospital of Palermo. Increased rotavirus activity usually occurred from the beginning of winter to mid-spring. G1P[8] rotaviruses were the prevalent strains in most of the years and were only occasionally overcome by G9P[8], G4P[8] or G2P[4]. The circulation of non-G1P[8] strains was discontinuous and fluctuating. Phylogenetic analyses revealed an heterogeneous population of viruses within each genotype, with different lineages and sublineages emerging over the time. Amino acid substitutions in both VP7 and VP8∗ antigenic epitopes were generally associated with different lineages/sublineages, emerging sequentially and replacing partially or completely the former strains. The present study summarises one of the longest surveillance activities conducted in the European continent, offering a useful temporal observatory of rotavirus epidemiology and strains variation and evolution in a settled population.
Lingua originaleEnglish
pagine (da-a)377-384
Numero di pagine8
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2400.2404???
  • ???subjectarea.asjc.1100.1105???
  • ???subjectarea.asjc.1300.1312???
  • ???subjectarea.asjc.1300.1311???
  • ???subjectarea.asjc.2700.2726???
  • ???subjectarea.asjc.2700.2725???


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