Cytotoxic activity of some natural and synthetic kauranes

Gabriella Bellone, Antonella Maria Maggio, Sergio Rosselli, Maurizio Bruno, Kuo-Hsiung Lee, Tzu-Hsuan Chen, Kenneth F. Bastow

Risultato della ricerca: Article

16 Citazioni (Scopus)

Abstract

Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 mu M, respectively. These two 1-analogues are promising lead compounds for further investigation.
Lingua originaleEnglish
pagine (da-a)347-352
Numero di pagine6
RivistaJournal of Natural Products
Volume70
Stato di pubblicazionePublished - 2007

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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