Cytotoxic activity of some natural and synthetic guaianolides

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44 Citazioni (Scopus)

Abstract

Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain
Lingua originaleEnglish
pagine (da-a)1042-1046
Numero di pagine5
RivistaJournal of Natural Products
Volume68
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • Plant Science
  • Chemistry (miscellaneous)
  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Organic Chemistry
  • Drug Discovery

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