Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)

Maurizio Bruno; Sergio Rosselli; Mariem Ben Jemia; Stefania Marzocco; Giuseppina Autore; Felice Senatore; Carmen Formisano

Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)

Maurizio Bruno, Sergio Rosselli, Mariem Ben Jemia, Stefania Marzocco, Giuseppina Autore, Felice Senatore, Carmen Formisano

Risultato della ricerca: Article › peer review

21 Citazioni (Scopus)

Abstract

The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.

Lingua originale	English
pagine (da-a)	1571-1578
Numero di pagine	8
Rivista	Molecules
Volume	20
Stato di pubblicazione	Published - 2015

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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@article{42c18cfea4f842f192f327561b92d1df,

title = "Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)",

abstract = "The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.",

keywords = "Bergaptene, Coumarins, Furanocoumarins, Isopimpinellin, MCF-7, Magydaris tomentosa, Osthole, Xanthotoxin, Xanthotoxol, Bergaptene, Coumarins, Furanocoumarins, Isopimpinellin, MCF-7, Magydaris tomentosa, Osthole, Xanthotoxin, Xanthotoxol",

author = "Maurizio Bruno and Sergio Rosselli and Jemia, {Mariem Ben} and Stefania Marzocco and Giuseppina Autore and Felice Senatore and Carmen Formisano",

year = "2015",

language = "English",

volume = "20",

pages = "1571--1578",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

}

TY - JOUR

T1 - Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)

AU - Bruno, Maurizio

AU - Rosselli, Sergio

AU - Jemia, Mariem Ben

AU - Marzocco, Stefania

AU - Autore, Giuseppina

AU - Senatore, Felice

AU - Formisano, Carmen

PY - 2015

Y1 - 2015

N2 - The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.

AB - The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-methoxy-8-(2-formyl-2-methylpropyl) coumarin and osthole also occurred. The antiproliferative activity of Magydaris tomentosa flower extract has been evaluated in vitro on murine monocye/macrophages (J774A.1), human melanoma (A375) and human breast cancer (MCF-7) tumor cell lines, showing a major activity against the latter.

KW - Bergaptene

KW - Coumarins

KW - Furanocoumarins

KW - Isopimpinellin

KW - MCF-7

KW - Magydaris tomentosa

KW - Osthole

KW - Xanthotoxin

KW - Xanthotoxol

KW - Bergaptene

KW - Coumarins

KW - Furanocoumarins

KW - Isopimpinellin

KW - MCF-7

KW - Magydaris tomentosa

KW - Osthole

KW - Xanthotoxin

KW - Xanthotoxol

UR - http://hdl.handle.net/10447/253291

UR - http://www.mdpi.com/1420-3049/20/1/1571/pdf

M3 - Article

VL - 20

SP - 1571

EP - 1578

JO - Molecules

JF - Molecules

SN - 1420-3049

ER -