Cytokine- and interferon-modulating properties of Echinacea spp. root tinctures stored at -20 degrees C for 2 years

Filippo Macaluso, Avery Solco, Yi Liu, David S. Senchina, Marian L. Kohut, Patricia A. Murphy, Dustin A. Mccann

    Risultato della ricerca: Articlepeer review

    15 Citazioni (Scopus)

    Abstract

    Echinacea spp. phytomedicines are popular for treating upper respiratory infections. The purpose of this investigation was to examine the immunomodulatory properties of Echinacea tinctures from seven species after being stored at -20 degrees C for 2 years. Two experimental techniques were employed using human peripheral blood mononuclear cells (PBMC). In the first set of experiments, PBMCs were stimulated in vitro with tinctures alone and assayed for proliferation and production of interleukin-10 (IL-10), IL-12, and tumor necrosis factor-alpha (TNF-alpha). In the second set of experiments, subjects were immunized with influenza vaccine. PBMCs from vaccinated individuals were stimulated in vitro with Echinacea tinctures and influenza virus; cytokine production (IL-2, IL-10, and interferon-gamma [IFN-gamma]) was compared prevaccination and postvaccination. In the first experiments, (1) tinctures from E. angustifolia, E. pallida, E. paradoxa, and E. tennesseensis stimulated proliferation and tended to increase IL-10, (2) E. sanguinea and E. simulata stimulated only proliferation, (3) E. purpurea stimulated only IL-10, and (4) none of the extracts influenced IL-12 or TNF-alpha. In the second experiments, (1) tinctures from E. pallida, E. paradoxa, E. sanguinea, and E. simulata diminished influenza-specific IL-2, and (2) none of the extracts influenced influenza-specific IL-10 or IFN-gamma. For in vitro models using Echinacea, immune response may vary based on stimulus (Echinacea alone vs. Echinacea + recall stimulation with virus).
    Lingua originaleEnglish
    pagine (da-a)425-436
    Numero di pagine12
    RivistaJournal of Interferon and Cytokine Research
    Volume27
    Stato di pubblicazionePublished - 2007

    All Science Journal Classification (ASJC) codes

    • ???subjectarea.asjc.2400.2403???
    • ???subjectarea.asjc.1300.1307???
    • ???subjectarea.asjc.2400.2406???

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