CYSTATIN C LEVELS ARE DECREASED IN ACUTE MYOCARDIAL INFARCTION. EFFECT OF CYSTATIN C G73A GENE POLYMORPHISM ON PLASMA LEVELS

Noto D; Cefalu' Ab; Barbagallo Cm; Pace A; Rizzo M; Marino G; Caldarella R; Castello A; Pernice V; Notarbartolo A; Averna M

Risultato della ricerca: Article

28 Citazioni (Scopus)

Abstract

BACKGROUND: Cystatin C is the most abundant protease inhibitor in the plasma. Low plasma levels have been found in patients with aortic aneurysms and they seem correlated with the extension of the aortic lesions in early aneurysms detected by ultrasonography. METHODS: In this study, plasma levels of cystatin C have been investigated in patients with acute myocardial infarction (AMI), unstable angina and controls. The effect on plasma levels of the G73A polymorphism of the CST3 gene has been also evaluated. RESULTS: Patients with acute myocardial infarction showed significantly lower levels of cystatin C compared to unstable angina and controls, but levels were nearly normal in a week after the acute event. The genotype distribution of the G73A polymorphism was not different among the groups. Nevertheless, cystatin C levels decreased proportionally with the number of A alleles. Cystatin C levels were positively correlated with age, triglyceride/HDL cholesterol ratio and creatinine, and negatively with HDL cholesterol and the number of A alleles. All variables, but not HDL cholesterol, were independently correlated in a multivariate analysis. CONCLUSIONS: Cystatin C is decreased in acute myocardial infarction. It is still not clear whether lower cystatin C levels are causally linked to the acute event or just represent a negative acute phase response. The CST3 gene G73A polymorphism functionally affects cystatin C plasma levels.
Lingua originaleEnglish
pagine (da-a)213-217
Numero di pagine5
RivistaInternational Journal of Cardiology
Volume101
Stato di pubblicazionePublished - 2005

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Cystatin C
Myocardial Infarction
Genes
HDL Cholesterol
Unstable Angina
Alleles
Acute-Phase Reaction
Aortic Aneurysm
Protease Inhibitors
Aneurysm
Ultrasonography
Creatinine
Triglycerides
Multivariate Analysis
Genotype

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cita questo

Noto D; Cefalu' Ab; Barbagallo Cm; Pace A; Rizzo M; Marino G; Caldarella R; Castello A; Pernice V; Notarbartolo A; Averna M (2005). CYSTATIN C LEVELS ARE DECREASED IN ACUTE MYOCARDIAL INFARCTION. EFFECT OF CYSTATIN C G73A GENE POLYMORPHISM ON PLASMA LEVELS. International Journal of Cardiology, 101, 213-217.

CYSTATIN C LEVELS ARE DECREASED IN ACUTE MYOCARDIAL INFARCTION. EFFECT OF CYSTATIN C G73A GENE POLYMORPHISM ON PLASMA LEVELS. / Noto D; Cefalu' Ab; Barbagallo Cm; Pace A; Rizzo M; Marino G; Caldarella R; Castello A; Pernice V; Notarbartolo A; Averna M.

In: International Journal of Cardiology, Vol. 101, 2005, pag. 213-217.

Risultato della ricerca: Article

Noto D; Cefalu' Ab; Barbagallo Cm; Pace A; Rizzo M; Marino G; Caldarella R; Castello A; Pernice V; Notarbartolo A; Averna M 2005, 'CYSTATIN C LEVELS ARE DECREASED IN ACUTE MYOCARDIAL INFARCTION. EFFECT OF CYSTATIN C G73A GENE POLYMORPHISM ON PLASMA LEVELS', International Journal of Cardiology, vol. 101, pagg. 213-217.
Noto D; Cefalu' Ab; Barbagallo Cm; Pace A; Rizzo M; Marino G; Caldarella R; Castello A; Pernice V; Notarbartolo A; Averna M. CYSTATIN C LEVELS ARE DECREASED IN ACUTE MYOCARDIAL INFARCTION. EFFECT OF CYSTATIN C G73A GENE POLYMORPHISM ON PLASMA LEVELS. International Journal of Cardiology. 2005;101:213-217.
Noto D; Cefalu' Ab; Barbagallo Cm; Pace A; Rizzo M; Marino G; Caldarella R; Castello A; Pernice V; Notarbartolo A; Averna M. / CYSTATIN C LEVELS ARE DECREASED IN ACUTE MYOCARDIAL INFARCTION. EFFECT OF CYSTATIN C G73A GENE POLYMORPHISM ON PLASMA LEVELS. In: International Journal of Cardiology. 2005 ; Vol. 101. pagg. 213-217.
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title = "CYSTATIN C LEVELS ARE DECREASED IN ACUTE MYOCARDIAL INFARCTION. EFFECT OF CYSTATIN C G73A GENE POLYMORPHISM ON PLASMA LEVELS",
abstract = "BACKGROUND: Cystatin C is the most abundant protease inhibitor in the plasma. Low plasma levels have been found in patients with aortic aneurysms and they seem correlated with the extension of the aortic lesions in early aneurysms detected by ultrasonography. METHODS: In this study, plasma levels of cystatin C have been investigated in patients with acute myocardial infarction (AMI), unstable angina and controls. The effect on plasma levels of the G73A polymorphism of the CST3 gene has been also evaluated. RESULTS: Patients with acute myocardial infarction showed significantly lower levels of cystatin C compared to unstable angina and controls, but levels were nearly normal in a week after the acute event. The genotype distribution of the G73A polymorphism was not different among the groups. Nevertheless, cystatin C levels decreased proportionally with the number of A alleles. Cystatin C levels were positively correlated with age, triglyceride/HDL cholesterol ratio and creatinine, and negatively with HDL cholesterol and the number of A alleles. All variables, but not HDL cholesterol, were independently correlated in a multivariate analysis. CONCLUSIONS: Cystatin C is decreased in acute myocardial infarction. It is still not clear whether lower cystatin C levels are causally linked to the acute event or just represent a negative acute phase response. The CST3 gene G73A polymorphism functionally affects cystatin C plasma levels.",
author = "{Noto D; Cefalu' Ab; Barbagallo Cm; Pace A; Rizzo M; Marino G; Caldarella R; Castello A; Pernice V; Notarbartolo A; Averna M} and Alberto Notarbartolo and Barbagallo, {Carlo Maria} and Maurizio Averna and Cefalu', {Angelo Baldassare} and Manfredi Rizzo and Valentina Pernice and Davide Noto",
year = "2005",
language = "English",
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pages = "213--217",
journal = "International Journal of Cardiology",
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T1 - CYSTATIN C LEVELS ARE DECREASED IN ACUTE MYOCARDIAL INFARCTION. EFFECT OF CYSTATIN C G73A GENE POLYMORPHISM ON PLASMA LEVELS

AU - Noto D; Cefalu' Ab; Barbagallo Cm; Pace A; Rizzo M; Marino G; Caldarella R; Castello A; Pernice V; Notarbartolo A; Averna M

AU - Notarbartolo, Alberto

AU - Barbagallo, Carlo Maria

AU - Averna, Maurizio

AU - Cefalu', Angelo Baldassare

AU - Rizzo, Manfredi

AU - Pernice, Valentina

AU - Noto, Davide

PY - 2005

Y1 - 2005

N2 - BACKGROUND: Cystatin C is the most abundant protease inhibitor in the plasma. Low plasma levels have been found in patients with aortic aneurysms and they seem correlated with the extension of the aortic lesions in early aneurysms detected by ultrasonography. METHODS: In this study, plasma levels of cystatin C have been investigated in patients with acute myocardial infarction (AMI), unstable angina and controls. The effect on plasma levels of the G73A polymorphism of the CST3 gene has been also evaluated. RESULTS: Patients with acute myocardial infarction showed significantly lower levels of cystatin C compared to unstable angina and controls, but levels were nearly normal in a week after the acute event. The genotype distribution of the G73A polymorphism was not different among the groups. Nevertheless, cystatin C levels decreased proportionally with the number of A alleles. Cystatin C levels were positively correlated with age, triglyceride/HDL cholesterol ratio and creatinine, and negatively with HDL cholesterol and the number of A alleles. All variables, but not HDL cholesterol, were independently correlated in a multivariate analysis. CONCLUSIONS: Cystatin C is decreased in acute myocardial infarction. It is still not clear whether lower cystatin C levels are causally linked to the acute event or just represent a negative acute phase response. The CST3 gene G73A polymorphism functionally affects cystatin C plasma levels.

AB - BACKGROUND: Cystatin C is the most abundant protease inhibitor in the plasma. Low plasma levels have been found in patients with aortic aneurysms and they seem correlated with the extension of the aortic lesions in early aneurysms detected by ultrasonography. METHODS: In this study, plasma levels of cystatin C have been investigated in patients with acute myocardial infarction (AMI), unstable angina and controls. The effect on plasma levels of the G73A polymorphism of the CST3 gene has been also evaluated. RESULTS: Patients with acute myocardial infarction showed significantly lower levels of cystatin C compared to unstable angina and controls, but levels were nearly normal in a week after the acute event. The genotype distribution of the G73A polymorphism was not different among the groups. Nevertheless, cystatin C levels decreased proportionally with the number of A alleles. Cystatin C levels were positively correlated with age, triglyceride/HDL cholesterol ratio and creatinine, and negatively with HDL cholesterol and the number of A alleles. All variables, but not HDL cholesterol, were independently correlated in a multivariate analysis. CONCLUSIONS: Cystatin C is decreased in acute myocardial infarction. It is still not clear whether lower cystatin C levels are causally linked to the acute event or just represent a negative acute phase response. The CST3 gene G73A polymorphism functionally affects cystatin C plasma levels.

UR - http://hdl.handle.net/10447/21400

M3 - Article

VL - 101

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EP - 217

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

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